Universal Infant Hepatitis B Virus (HBV) Vaccination for 35 Years: Moving Toward the Eradication of HBV

Author:

Chang Kai-Chi12,Chang Mei-Hwei13,Chen Huey-Ling134,Wu Jia-Feng1,Chang Chin-Hao5,Hsu Hong-Yuan14,Ni Yen-Hsuan13

Affiliation:

1. Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan

2. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

3. Hepatitis Research Center, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan

4. Medical Education and Bioethics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan

5. Medical Research, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan

Abstract

Abstract A universal hepatitis B virus (HBV) vaccination program has been implemented in Taiwan since 1984. A total of 1611 individuals in Taipei were enrolled to monitor long-term efficacy. The prevalences of hepatitis B surface antigen (HBsAg) and hepatitis B core antibody in the vaccinated birth cohort were lower than in those born before 1984 (0.4% vs 7.7%, and 2.2% vs 50.8%, respectively; P < .0001). Three vaccine-failure carriers all were born to HBsAg-carrier mothers, probably due to no antiviral intervention during pregnancy. Occult HBV infection was rare in the postvaccination era. High vaccination coverage, comprehensive HBV screening, and antiviral agents for pregnant mothers will be essential to eliminate HBV transmission.

Funder

Center for Disease Control, Department of Health, Taiwan

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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