Challenges of Discrepant HIV Tests in Pregnant Women in the PrEP era—to Treat or Not to Treat?-Reference-Cited by-同舟云学术

Challenges of Discrepant HIV Tests in Pregnant Women in the PrEP era—to Treat or Not to Treat?

Published:2020-06-19 Issue:2 Volume:223 Page:234-237
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Wagner Anjuli D¹^ORCID,Kinuthia John²,Dettinger Julia¹,Mwongeli Nancy²,Gómez Laurén¹,Watoyi Salphine²,Drake Alison L¹³,Abuna Felix²,Pintye Jillian¹^ORCID,Ochieng Ben²,Odinga Daniel²,John-Stewart Grace¹³⁴⁵,Baeten Jared M¹³⁴

Affiliation:

1. Department of Global Health, University of Washington, Seattle, Washington, USA

2. Research and Programs, Kenyatta National Hospital, Nairobi, Kenya

3. Department of Epidemiology, University of Washington, Seattle, Washington, USA

4. Department of Medicine, University of Washington, Seattle, Washington, USA

5. Department of Pediatrics, University of Washington, Seattle, Washington, USA

Abstract

Abstract Background During HIV retesting in antenatal and preexposure prophylaxis (PrEP) care, discrepant results occur, but guidelines are lacking. Methods In a Kenyan trial implementing antenatal PrEP, if 1 test is reactive, a second is performed; if discrepant, both are repeated; if persistently discrepant, DNA polymerase chain reaction (PCR) is performed. Results Among 4451 women, 23 265 HIV retesting sessions were performed; 14 (0.06%, 95% confidence interval, 0.03%–0.10%) had discrepant results among 10 individuals; in all 10 initial cases, PCR was negative. Conclusions Discrepant rapid tests are an expected, rare, and important challenge for antenatal care HIV retesting, with and without PrEP. Clinical Trials Registration NCT03070600.

Funder

National Institutes of Health

University of Washington Center for AIDS Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa343/33521405/jiaa343.pdf

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