A Knockout IFNL4 Variant Is Associated With Protection From Sexually Transmitted HIV-1 Infection

Author:

Jaimes-Bernal Claudia12,Rallón Norma34,Benito José M34,Omar Mohamed5,Gómez-Vidal María Amparo5,Márquez Francisco José1,Sánchez-Arcas Beatriz1,Trujillo Monte6,Royo José Luis7,Saulle Irma8,Biasin Mara8,Rivero-Juárez Antonio9,Caruz Antonio1ORCID

Affiliation:

1. Immunogenetics Unit, Department of Experimental Biology, Universidad de Jaén, Jaen

2. Research Group of the Bacteriology and Clinical Laboratory Program, Faculty of Health Sciences, Universidad de Boyacá, Tunja, Colombia

3. Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid

4. Hospital Universitario Rey Juan Carlos, Móstoles

5. Infectious Diseases and Clinical Microbiology Unit. Complejo Hospitalario de Jaén, Jaen

6. Transfusion Blood Center, Jaen

7. Department of Surgery, Biochemistry and Immunology, Universidad de Málaga, Málaga

8. Department of Biomedical and Clinical Sciences “L.-Sacco”, University of Milan, Italy

9. Maimonides Institute for Research in Biomedicine of Cordoba/Hospital Universitario Reina Sofía, Cordoba, Spain

Funder

Ministerio de Economía, Industria y Competitividad

Asociación Universitaria Iberoamericana de Postgrado

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference15 articles.

1. Genetic and immune determinants of immune activation in HIV-exposed seronegative individuals and their role in protection against HIV infection;Fenizia;Infect Genet Evol,2017

2. The impact of host genetic variation on infection with HIV-1;McLaren;Nat Immunol,2015

3. Interferon lambda genetics and biology in regulation of viral control;Hemann;Front Immunol,2017

4. A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus;Prokunina-Olsson;Nat Genet,2013

5. IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals;Machmach;Clin Microbiol Infect,2015

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