High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis

Author:

Depledge Daniel P1,Cudini Juliana1,Kundu Samit2,Atkinson Claire3,Brown Julianne R4,Haque Tanzina3,Houldcroft Charlotte J1,Koay Evelyn S56,McGill Fiona789,Milne Richard1,Whitfield Tom7,Tang Julian W1011,Underhill Gillian12,Bergstrom Tomas6,Norberg Peter6,Goldstein Richard1,Solomon Tom13,Breuer Judith1

Affiliation:

1. Division of Infection and Immunity, University College London

2. School of Human and Life Sciences, Canterbury Christ Church University, University of Kent

3. Department of Virology, Royal Free Hospital, London

4. Microbiology, Virology and Infection Prevention and Control, Great Ormond Street Hospital NHS Foundation Trust, London

5. Department of Pathology, National University of Singapore

6. Department of Infectious Diseases, Section for Clinical Virology, Institute of Biomedicine, University of Gothenburg, Sweden

7. Institute of Infection and Global Health, University of Liverpool

8. National Institute for Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool

9. Royal Liverpool University Hospitals

10. Clinical Microbiology, University Hospitals of Leicester NHS Trust

11. Molecular Diagnosis Centre, National University Hospital, Singapore

12. Departments of Clinical Microbiology, Pathology Centre, Queen Alexandra Hospital, Portsmouth

13. Walton Centre NHS Foundation Trust, Liverpool, United Kingdom

Funder

MRC

UCL/UCLH BRC

Action Medical Research

Swedish Research Council

NIHR

Meningitis Research Foundation

NIHR Health Protection Research Unit in Emerging and Zoonotic Infections

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference23 articles.

1. Varicella-zoster virus: aspects of pathogenesis and host response to natural infection and varicella vaccine;Arvin;Adv Virus Res,1996

2. Immune responses to varicella-zoster in the aged;Burke;Arch Intern Med,1982

3. Varicella-zoster virus CNS disease–viral load, clinical manifestations and sequels;Persson;J Clin Virol,2009

4. A point mutation in a herpesvirus polymerase determines neuropathogenicity;Goodman;PLoS Pathog,2007

5. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data;McKenna;Genome Res,2010

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