Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe-Reference-Cited by-同舟云学术

Steep Rebound of Chloroquine-Sensitive Plasmodium falciparum in Zimbabwe

Published:2020-06-28 Issue:2 Volume:223 Page:306-309
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Mharakurwa Sungano¹,Matsena-Zingoni Zvifadzo²,Mudare Nobert¹,Matimba Charmaine¹,Gara Tanatswa Xuxa¹,Makuwaza Aramu²,Maponga Gladys²,Munyati Shungu³,Gwanzura Lovemore³⁴,Mutambu Susan L¹,Mason Peter³,Kobayashi Tamaki⁵⁶,Midzi Nicholas²,Moss William J⁵⁶,Ippolito Matthew M⁶⁷

Affiliation:

1. Department of Health Sciences, Africa University, Mutare, Zimbabwe

2. National Institute of Health Research Malaria Section, Harare, Zimbabwe

3. Biomedical Research and Training Institute, Harare, Zimbabwe

4. College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe

5. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

6. Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

7. Division of Clinical Pharmacology and Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Abstract

Abstract Removal of chloroquine from national malaria formularies can lead to the reversion of resistant Plasmodium falciparum to wild-type. We report a steep decline in chloroquine-resistant P falciparum within 10 years of national discontinuation of chloroquine monotherapy in Zimbabwe. Drug resistance surveillance is a vital component of malaria control programs, and the experience with chloroquine in Zimbabwe and elsewhere in sub-Saharan Africa is illustrative of the potentially rapid and dramatic impact of drug policy on antimalarial resistance.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

International Centers of Excellence for Malaria Research

Johns Hopkins Malaria Research Institute

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa368/33524664/jiaa368.pdf

Reference16 articles.