Neurofilament Light Chain as a Biomarker of Neuronal Damage in Children With Malaria-Reference-Cited by-同舟云学术

Neurofilament Light Chain as a Biomarker of Neuronal Damage in Children With Malaria

Published:2023-08-30 Issue:1 Volume:229 Page:183-188
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Balanza Núria¹^ORCID,Francis Caroline K²,Crowley Valerie M²^ORCID,Weckman Andrea M²³^ORCID,Zhong Kathleen²,Baro Bàrbara¹^ORCID,Varo Rosauro¹⁴^ORCID,Bassat Quique¹⁴⁵⁶⁷^ORCID,Kain Kevin C²³^ORCID,Mayor Alfredo,Manhiça Ana Rosa,Cossa Anelsio,Sitoe Antonio,Mucasse Campos,Erice Clara,Fonseca Crisóstomo,Mucasse Humberto,Bramugy Justina,Quimice Lazaro,Serghides Lena,Valente Marta,Gladstone Melissa,Vitorino Pio,Bila Rubao,Ajanovic Sara,Derpsch Yiovanna,

Affiliation:

1. ISGlobal, Hospital Clinic–University of Barcelona , Barcelona , Spain

2. Sandra-Rotman Centre for Global Health, Toronto General Research Institute, University Health Network–Toronto General Hospital, Toronto, Ontario, Canada

3. Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto , Toronto, Ontario , Canada

4. Centro de Investigação em Saúde de Manhiça , Maputo , Mozambique

5. Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain

6. Pediatrics Department, Hospital Sant Joan de Déu–‌‌‌University of Barcelona, Barcelona, Spain

7. Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública , Madrid , Spain

Abstract

Abstract Malaria can cause brain injury. Neurofilament light chain (NfL) is a biomarker of neuronal damage. Here we examined longitudinal plasma NfL levels in children aged 1–12 years with uncomplicated and severe malaria from Mozambique. NfL levels were similar in all malaria cases at hospital admission. However, levels increased over time and the increment was significantly higher in severe malaria cases with neurological manifestations (ie, coma, impaired consciousness, or repeated seizures). NfL may be useful to identify and quantify brain injury in malaria.

Funder

Canadian Institutes of Health Research

Canada Research Chair in Molecular Parasitology

Thomas Mather Fund

Spanish Ministry of Science and Innovation

Generalitat de Catalunya

Fundación Ramón Areces

Centro de Investigação em Saúde de Manhiça

Government of Mozambique and the Spanish Agency for International Development

Spanish Ministry of Universities

Government of Catalonia’s Secretariat for Universities and Research

Marie Sklodowska-Curie Actions COFUND Program