Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial
Author:
Rouphael Nadine G1ORCID, Branche Angela R2, Diemert David J3ORCID, Falsey Ann R2, Losada Cecilia1, Baden Lindsey R4, Frey Sharon E5, Whitaker Jennifer A6, Little Susan J7, Kamidani Satoshi89ORCID, Walter Emmanuel B10, Novak Richard M11, Rupp Richard12, Jackson Lisa A13, Babu Tara M14, Kottkamp Angelica C15, Luetkemeyer Anne F16, Immergluck Lilly C17, Presti Rachel M18, Bäcker Martín19, Winokur Patricia L20, Mahgoub Siham M21, Goepfert Paul A22ORCID, Fusco Dahlene N23, Atmar Robert L6, Posavad Christine M2425, Netzl Antonia26, Smith Derek J26, Telu Kalyani27, Mu Jinjian27, McQuarrie Lisa J27, Makowski Mat27, Makhene Mamodikoe K28, Crandon Sonja28, Montefiori David C29, Roberts Paul C28, Beigel John H28, Diemert David J, Malkin Elissa, Bethony Jeffrey M, Desrosiers Aimee, Siegel Marc, Branche Angela R, Falsey Ann R, Walsh Edward, Kingsley Patrick, Peasley Michael, Rouphael Nadine G, Losada Cecilia, Graciaa Daniel S, Samaha Hady, Rebolledo Paulina A, Wiley Zanthia, Baden Lindsey R, Sherman Amy C, Walsh Stephen R, Tong Alexandra, Rooks Rebecca, Frey Sharon E, Abate Getahun, Oikonomopoulou Zacharoula, Hoft Daniel F, Graham Irene, Whitaker Jennifer A, El Sahly Hana M, Keitel Wendy A, Healy C Mary, Atmar Robert L, Little Susan J, Martin Thomas C S, Carter Nicole, Hendrickx Steven, Anderson Evan J, Rostad Christina A, Kamidani Satoshi, Peters Etza, Walter Emmanuel B, Smith Michael J, Moody M Anthony, Schmader Kenneth E, Novak Richard M, Ladner Benjamin G, Wendrow Andrea, Herrick Jessica, Rupp Richard, Porterfield Laura, Jackson Lisa A, Dunstan Maya, Lau Rebecca, Carste Barbara, Babu Tara M, Wald Anna, Krause Taylor, Hauge Kirsten, Kottkamp Angelica C, Mulligan Mark J, Davis Tamia, Engelson Celia, Soma Vijaya, Luetkemeyer Anne F, Harris Chloe, Lopez Azquena Munoz, Immergluck Lilly C, Johnson Erica, Chan Austin, Presti Rachel M, O’Halloran Jane A, Thompson Ryley M, Bäcker Martín, Fleming Andrew B, Joseph Sajumon, Winokur Patricia L, Meier Jeffery, Stapleton Jack, Mahgoub Siham M, Maxwell Celia, Shami Sarah, Goepfert Paul A, Fusco Dahlene N, Drouin Arnaud C, Numbi Florice K, Lyke Kirsten E, Stephens David S, Neuzil Kathleen M, Farley Monica M, Marrazzo Jeanne, Young Sidnee Paschal, Lennox Jeffery, Atmar Robert L, McNeil Linda, Brown Elizabeth, Posavad Christine M, Meagher Megan A, McElrath Julie, Gale Mike, Abebe Kuleni, Makowski Mat, Hill Heather, Albert Jim, Baughman Holly, McQuarrie Lisa, Telu Kalyani, Mu Jinjian, McQuarrie Lisa J, Lewis Teri C, Giebeig Lisa A, Engel Theresa M, Griffith Caleb J, McDonald Wendi L, Burkey Alissa E, Hoopengardner Lisa B, Linton Jessica E, Gettinger Nikki L, Montefiori David C, Eaton Amanda, Smith Derek J, Netzl Antonia, Wilks Samuel H, Türeli Sina, Makhene Mamodikoe, Elsafy Mohamed, Pikaart-Tautges Rhonda, Arega Janice, Hoang Binh, Curtin Dan, Koo Hyung, Sindall Elisa, Crandon Sonja, DeGrace Marciela M, Post Diane J, Nayak Seema U, Roberts Paul C, Beigel John H,
Affiliation:
1. Hope Clinic, Emory University , D ecatur, Georgia 2. Vaccine and Treatment Evaluation Unit, University of Rochester , N ew York 3. George Washington Vaccine Research Unit, George Washington University , Washington, District of Columbia 4. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School , Boston, Massachusetts 5. Center for Vaccine Development, Saint Louis University , Missouri 6. Department of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine , Houston, Texas 7. Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego , La Jolla 8. Center for Childhood Infections and Vaccines, Children’s Healthcare of Atlanta 9. Department of Pediatrics, Emory University , Atlanta, Georgia 10. Duke Human Vaccine Institute, Duke University School of Medicine , Durham, North Carolina 11. Project WISH, University of Illinois at Chicago, Chicago, Illinois 12. Department of Pediatrics, University of Texas Medical Branch , Galveston, Texas 13. Kaiser Permanente Washington Health Research Institute , Seattle, Washington 14. Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington , S eattle, Washington 15. Vaccine and Treatment Evaluation Unit, Manhattan Research Clinic, New York University Grossman School of Medicine , New York, New York 16. Department of Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, California 17. Clinical Research Center, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine , Atlanta, Georgia 18. Department of Medicine, Washington University School of Medicine , St Louis, Missouri 19. Vaccine and Treatment Evaluation Unit, Long Island Research Clinic, New York University Long Island School of Medicine , Mineola, New York 20. Department of Medicine, University of Iowa College of Medicine , Iowa City, Iowa 21. Howard University College of Medicine, Howard University Hospital , Washington, District of Columbia 22. Department of Medicine, University of Alabama at Birmingham , Al abama 23. Department of Medicine, Tulane University School of Medicine , New Orleans, Louisiana 24. Infectious Diseases Clinical Research Consortium (IDCRC) Laboratory Operations Unit, Fred Hutchinson Cancer Center, Seattle, Washington 25. Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington 26. Centre for Pathogen Evolution, Department of Zoology, University of Cambridge , United Kingdom 27. The Emmes Company, LLC , Rockville, Maryland 28. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 29. Department of Surgery, Duke University , Durham, North Carolina
Abstract
Abstract
We compared the serologic responses of 1 dose versus 2 doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A 2-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.
Funder
Department of Health and Human Services US government
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Immunology and Allergy
Cited by
1 articles.
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