Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria-Reference-Cited by-同舟云学术

Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria

Published:2018-10-15 Issue:4 Volume:219 Page:660-671
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Loughland Jessica R¹,Woodberry Tonia¹,Boyle Michelle J¹²,Tipping Peta E¹,Piera Kim A¹,Amante Fiona H³,Kenangalem Enny⁴⁵,Price Ric N¹⁶,Engwerda Christian R³,Anstey Nicholas M¹,McCarthy James S³,Minigo Gabriela¹

Affiliation:

1. Menzies School of Health Research and Charles Darwin University, Darwin, Australia

2. Burnet Institute, Melbourne, Victoria, Australia

3. QIMR Berghofer Medical Research Institute, Brisbane, Australia

4. Timika Malaria Research Program, Papuan Health and Community Development Foundation, Indonesia

5. District Health Authority, Timika, Papua, Indonesia

6. Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

Abstract

This study identified CD16+ DCs as the only blood DC subset distinctively activated during primary blood-stage human Plasmodium infection. As TNF/IL-10 coproducers, CD16+ DCs contribute to early inflammatory processes, yet P falciparum restimulation skewed cytokine responses further towards IL-10 production.

Funder

National Health and Medical Research Council

Channel 7 Children’s Research Foundation

Medicines for Malaria Venture

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/219/4/660/27636933/jiy555.pdf

Reference49 articles.