Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza-Reference-Cited by-同舟云学术

Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza

Published:2022-04-27 Issue:10 Volume:226 Page:1800-1808
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Okuda Moe¹,Sakai-Tagawa Yuko¹²,Koga Michiko³,Koibuchi Tomohiko⁴,Kikuchi Tadashi⁴,Adachi Eisuke⁴,Ahyoung Lim Lay⁴,Yamamoto Shinya¹³,Yotsuyanagi Hiroshi³⁴,Negishi Kyota⁵,Jubishi Daisuke⁵⁶,Yamayoshi Seiya¹²⁷^ORCID,Kawaoka Yoshihiro¹²⁷⁸

Affiliation:

1. Department of Virology, Institute of Medical Science, University of Tokyo , Tokyo , Japan

2. International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo , Tokyo , Japan

3. Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo , Tokyo , Japan

4. Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, the University of Tokyo , Tokyo , Japan

5. Tokyo Health Cooperative Association, Nezu Clinic , Tokyo , Japan

6. Department of Infectious Diseases, The University of Tokyo Hospital , Tokyo , Japan

7. The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute , Tokyo , Japan

8. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison , Madison, Wisconsin , USA

Abstract

Abstract On influenza virus infection or vaccination, immune responses occur, including the production of antibodies with various functions that contribute to protection from seasonal influenza virus infection. In the current study, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus. For antibody titers before influenza virus exposure, we found that the nAb titers and enzyme-linked immunosorbent assay titers against hemagglutinin and neuraminidase (NA) proteins in the subclinically infected individuals were significantly higher than those in the patients, whereas the NA inhibition titers and antibody-dependent cellular cytotoxicity activities did not significantly differ between subclinically infected individuals and infected patients. These results suggest that nAb and enzyme-linked immunosorbent assay titers against hemagglutinin and NA serve as correlates of symptomatic influenza infection.

Funder

Japan Program for Infectious Diseases Research and Infrastructure

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science Kakenhi

National Institutes of Allergy and Infectious Diseases

Center for Research on Influenza Pathogenesis

NIH

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac152/43858846/jiac152.pdf

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