Upregulation ofPTPRCand Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection

Author:

Li Yunqi1ORCID,Lefebvre Francois2,Nakku-Joloba Edith3,Ronald Allan4,Gray Glenda5,de Bruyn Guy5,Kiarie James67,Celum Connie789,Cameron Mark J10,Lingappa Jairam R7811,Mackelprang Romel D712

Affiliation:

1. Institute for Public Health Genetics, University of Washington , Seattle, Washington , USA

2. Canadian Centre for Computational Genomics-Montréal Node , Montreal, Quebec , Canada

3. School of Public Health, Makerere University , Kampala , Uganda

4. Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg , Canada

5. Perinatal HIV Research Unit, University of the Witwatersrand , Johannesburg , South Africa

6. Department of Obstetrics and Gynecology, University of Nairobi , Nairobi , Kenya

7. Department of Global Health, University of Washington , Seattle, Washington , USA

8. Department of Medicine, University of Washington , Seattle, Washington , USA

9. Department of Epidemiology, University of Washington , Seattle, Washington , USA

10. Department of Population and Quantitative Health Science, Case Western Reserve University , Cleveland, Ohio , USA

11. Department of Pediatrics, University of Washington , Seattle, Washington , USA

12. Department of Obstetrics and Gynecology, University of Washington , Seattle, Washington , USA

Abstract

AbstractHuman immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in which couples’ HIV-1 exposures were quantified based on unprotected sex frequency and viral load of the partner with HIV-1. We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus may be a signature for increased acquisition risk.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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