The Effect of Interrupted/Deferred Antiretroviral Therapy on Disease Risk: A SMART and START Combined Analysis

Author:

Borges Álvaro H1,Neuhaus Jacqueline2,Sharma Shweta2,Neaton James D2,Henry Keith3,Anagnostou Olga4,Staub Teresa5,Emery Sean6,Lundgren Jens D1, ,

Affiliation:

1. Center of Excellence for Health, Infections and Immunity, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Denmark

2. Division of Biostatistics, School of Public Health, University of Minnesota

3. Hennepin County Medical Center, Minneapolis, Minnesota

4. University of Athens, Greece

5. Centre Hospitalier de Luxembourg, Service des Maladies Infectieuses, Luxembourg

6. Faculty of Medicine, University of Queensland, Brisbane, Australia

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Agence Nationale de Recherches sur le SIDA et les Hipatites Virales

National Health and Medical Research Council

Danish National Research Foundation

Bundesministerium für Bildung und Forschung

European AIDS Treatment Network

Medical Research Council

National Institute for Health Research

National Health Service

University of Minnesota

AbbVie

Bristol-Myers Squibb

Gilead Sciences

GlaxoSmithKline

ViiV Healthcare

Janssen Scientific Affairs

Merck

Rigshospitalet

Lundbeckfonden

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference20 articles.

1. CD4+ count-guided interruption of antiretroviral treatment;El-Sadr;N Engl J Med,2006

2. Initiation of antiretroviral therapy in early asymptomatic HIV infection;Lundgren;N Engl J Med,2015

3. A trial of early antiretrovirals and isoniazid preventive therapy in Africa;Danel;N Engl J Med,2015

4. Antiretroviral therapy for the prevention of HIV-1 transmission;Cohen;N Engl J Med,2016

5. Considerations in the rationale, design and methods of the Strategic Timing of AntiRetroviral Treatment (START) study;Babiker;Clin Trials,2013

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