Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu Infection
Author:
Uriu Keiya1, Cárdenas Paúl2, Muñoz Erika2, Barragan Veronica2, Kosugi Yusuke1, Shirakawa Kotaro3, Takaori-Kondo Akifumi3, Ito Jumpei, Yamasoba Daichi, Kimura Izumi, Suganami Mai, Oide Akiko, Yokoyama Miyabishara, Chiba Mika, Nakagawa So, Wu Jiaqi, Takahashi Miyoko, Kazuma Yasuhiro, Nomura Ryosuke, Horisawa Yoshihito, Nagata Kayoko, Yanagida Yohei, Kawai Yugo, Tashiro Yusuke, Kaneda Atsushi, Nakada Taka-aki, Seki Motoaki, Fujiki Ryoji, Shimada Tadanaga, Hirahara Kiyoshi, Yokote Koutaro, Nakayama Toshinori, Irie Takashi, Kawabata Ryoko, Morizako Nanami, Fukuhara Takasuke, Shimizu Kenta, Tsushima Kana, Kubo Haruko, Ikeda Terumasa, Motozono Chihiro, Nasser Hesham, Shimizu Ryo, Yuan Yue, Kitazato Kazuko, Hasebe Haruyo, Ueno Takamasa, Saito Akatsuki, Butlertanaka Erika P, Tanaka Yuri L, Tokunaga Kenzo, Ozono Seiya, Sadamasu Kenji, Asakura Hiroyuki, Yoshida Isao, Nagashima Mami, Yoshimura Kazuhisa, Márquez Sully, Prado-Vivar Belén, Becerra-Wong Mónica, Carvajal Mateo, Trueba Gabriel, Rojas-Silva Patricio, Grunauer Michelle, Gutierrez Bernardo, Guadalupe Juan José, Fernández-Cadena Juan Carlos, Andrade-Molina Derly, Baldeon Manuel, Pinos Andrea, Sato Kei14ORCID,
Affiliation:
1. Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo , Tokyo , Japan 2. Institute of Microbiology, Universidad San Francisco de Quito , Quito , Ecuador 3. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University , Kyoto , Japan 4. CREST, Japan Science and Technology Agency , Saitama , Japan
Abstract
Abstract
Background
We have recently revealed that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mu variant shows a pronounced resistance to antibodies elicited by natural SARS-CoV-2 infection and vaccination.
Methods
However, it remains unclear which mutations determine the resistance of SARS-CoV-2 Mu to antiviral sera. In addition, it is unclear how SARS-CoV-2 Mu infection induces antiviral immunity.
Results
In this study, we reveal that the 2 mutations in the SARS-CoV-2 Mu spike protein, YY144-145TSN and E484K, are responsible for the resistance to coronavirus disease 2019 convalescent sera during early 2020 and vaccine sera.
Conclusions
It is notable that the convalescent sera of SARS-CoV-2 Mu-infected individuals are broadly antiviral against Mu as well as other SARS-CoV-2 variants of concern and interest.
Funder
AMED Research Program on Emerging and Re-emerging Infectious Diseases AMED Research Program on HIV/AIDS JST SICORP CREST KAKENHI Fostering Joint International Research JSPS Core-to-Core Program
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Immunology and Allergy
Cited by
25 articles.
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