The Mosaic mtr Locus as Major Genetic Determinant of Azithromycin Resistance of Neisseria gonorrhoeae

The Mosaic mtr Locus as Major Genetic Determinant of Azithromycin Resistance of Neisseria gonorrhoeae—Germany, 2018

Published:2021-02-16 Issue:8 Volume:224 Page:1398-1404
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Banhart Sebastian¹,Selb Regina²,Oehlmann Sandra¹,Bender Jennifer³⁴,Buder Susanne⁵,Jansen Klaus²,Heuer Dagmar¹

Affiliation:

1. Unit of Sexually Transmitted Bacterial Pathogens, Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany

2. Unit of HIV/AIDS, STI and Blood-borne Infections, Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany

3. Unit of Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany

4. European Programme for Public Health Microbiology Training, European Centre for Disease Prevention and Control, Solna, Sweden

5. German Reference Laboratory for Gonococci, Unit of Sexually Transmitted Bacterial Pathogens, Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany

Abstract

Abstract Within the German Gonococcal Resistance Network’s (GORENET) Neisseria gonorrhoeae (NG) sample collection, azithromycin-resistant NG isolates increased from 4.3% in 2016 to 9.2% in 2018. We aim to understand this observed increase using whole genome sequencing of NG isolates combined with epidemiological and clinical data. Reduced susceptibility to azithromycin in 2018 was predominately clonal (NG multiantigen sequence typing G12302) and could mainly be attributed to the recently described mosaic-like mtr locus. Our data suggest that, together with horizontal gene transfer of resistance determinants and well-established point mutations, international spread of resistant lineages plays a major role regarding azithromycin resistance in Germany.

Funder

German Federal Ministry of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiab091/38501614/jiab091.pdf

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2. Molecular epidemiological typing of Neisseria gonorrhoeae isolates identifies a novel association between genogroup G10557 (G7072) and decreased susceptibility to cefixime, Germany, 2014 to 2017;Banhart;Euro Surveill,2020

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