Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis-Reference-Cited by-同舟云学术

Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis

Published:2021-05-24 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Ydsten Karin A¹^ORCID,Hellgren Urban¹²,Asgeirsson Hilmir¹²

Affiliation:

1. Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden

2. Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden

Abstract

Abstract Background Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis. Methods Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008–2020, were retrospectively identified. Results Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and 3 combined with metronidazole. Only 3 had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy) and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded. Conclusions Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiab287/38835744/jiab287.pdf

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