Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception-Reference-Cited by-同舟云学术

Persistent Immune Activation in Human Immunodeficiency Virus–Infected Pregnant Women Starting Combination Antiretroviral Therapy After Conception

Published:2021-03-29 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Lohman-Payne Barbara¹^ORCID,Koster Jacob²,Gabriel Benjamin¹,Chilengi Roma³,Forman Leah S⁴,Heeren Tim⁵,Duffy Cassandra R⁶,Herlihy Julie⁷,Crimaldi Steven⁸,Gill Chris⁸,Chavuma Roy⁹¹⁰,Mwananyanda Lawrence⁸¹⁰,Thea Donald M⁸

Affiliation:

1. Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island, USA

2. National Emerging Infectious Diseases Laboratories, Boston University Medical Campus, Boston, Massachusetts, USA

3. Center for Infectious Disease Research Zambia, Lusaka, Zambia

4. Biostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, Massachusetts, USA

5. Departments of Biostatistics, Boston, Massachusetts, USA

6. Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

7. Department of Pediatrics, Boston, Massachusetts, USA

8. Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA

9. Department of Surgery, School of Medicine, University of Zambia, Lusaka, Zambia

10. Right to Care–Zambia, Lusaka, Zambia

Abstract

Abstract This study evaluated the impact of human immunodeficiency virus (HIV) and combination antiretroviral therapy (cART) on immune activation during pregnancy in a Zambian cohort of HIV-exposed but uninfected children followed up from birth. Activated CD8+ T cells (CD38+ and HLA-DR+) were compared among HIV-uninfected (n = 95), cART experienced HIV-infected (n = 111), and cART-naive HIV-infected (n = 21) pregnant women. Immune activation was highest among HIV-infected/cART-naive women but decreased during pregnancy. Immune activation HIV-infected women who started cART during pregnancy was reduced but not to levels similar to those in HIV-uninfected women. The effects of elevated maternal immune activation in pregnancy on subsequent infant health and immunity remain to be determined.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiab095/38714166/jiab095.pdf

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