Verapamil, and Its Metabolite Norverapamil, Inhibit Macrophage-induced, Bacterial Efflux Pump-mediated Tolerance to Multiple Anti-tubercular Drugs

Author:

Adams Kristin N.1,Szumowski John D.2,Ramakrishnan Lalita123

Affiliation:

1. Department of Microbiology

2. Department of Medicine, Division of Infectious Diseases

3. Department of Immunology, University of Washington, Seattle, Washington

Funder

NIH

the recipient of the Merle A. Sande-Pfizer Fellowship in International Infectious Diseases

NIH Director's Pioneer Award

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference50 articles.

1. Controlled clinical trial of short-course (6-month) regimens of chemotherapy for treatment of pulmonary tuberculosis;Lancet,1972

2. Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion;Johnson;Am J Respir Crit Care Med,2009

3. Why is long-term therapy required to cure tuberculosis?;Connolly;PLoS Med,2007

4. M. tuberculosis persistence, latency, and drug tolerance;Gomez;Tuberculosis,2004

5. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies;Barry;Nat Rev Microbiol,2009

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