What’s Sex Got to Do With It? Understanding Potential Confounding and Exposure Misclassification in Mechanistic Sexually Transmitted Infection Research-Reference-Cited by-同舟云学术

What’s Sex Got to Do With It? Understanding Potential Confounding and Exposure Misclassification in Mechanistic Sexually Transmitted Infection Research

Published:2020-11-12 Issue:1 Volume:224 Page:137-140
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Deese Jennifer¹^ORCID,Wang Meng²,Lapple Dana³,Nelson Julie A E⁴,Kuerten Bethany⁵,Steiner Markus J⁶,Chen Pai Lien⁷,Hobbs Marcia M³

Affiliation:

1. Global Public Health Impact Center, RTI International, Research Triangle Park, North Carolina, USA

2. Target PharmaSolutions, Durham, North Carolina, USA

3. Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

5. Upstream USA, Raleigh, North Carolina, USA

6. Product Development and Introduction, FHI 360, Durham, North Carolina, USA

7. Biostatistics, FHI 360, Durham, North Carolina, USA

Abstract

Abstract We conducted a prospective study of 13 heterosexual couples to understand the impact of recent condomless vaginal sex on vaginal immune marker measurement and potential exposure misclassification due to the presence of semen. All immune markers were detectable in semen and concentrations of vaginal immune markers varied by sex recency.

Funder

University of North Carolina at Chapel Hill Center for AIDS Research

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiaa705/35073642/jiaa705.pdf

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1. Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis;eLife;2022-10-25

2. Cervicovaginal immune mediators increase when young women begin to have sexual intercourse: a prospective study and meta-analysis;2022-04-01