Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial

Author:

Finberg Robert W1,Lanno Riin2,Anderson David3,Fleischhackl Roman4,van Duijnhoven Wilbert5,Kauffman Robert S6,Kosoglou Teddy3,Vingerhoets Johan7,Leopold Lorant3

Affiliation:

1. University of Massachusetts Medical School, Worcester

2. Merelahe Family Doctors Center, Tallinn, Estonia

3. Janssen Research and Development, Titusville, New Jersey

4. Janssen-Cilag, Vienna, Austria

5. Statistics and Decision Sciences, Quantitative Sciences

6. Vertex Pharmaceuticals, Boston, Massachusetts

7. Clinical Virology, Janssen Pharmaceutica, Beerse, Belgium

Funder

Janssen Research and Development

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference13 articles.

1. Randomized study of ondansetron versus domperidone in the treatment of children with acute gastroenteritis;Rerksuppaphol;J Clin Med Res,2013

2. Antivirals–current trends in fighting influenza;Król;Acta Biochim Pol,2014

3. Mortality and morbidity burden associated with A/H1N1pdm influenza virus: who is likely to be infected, experience clinical symptoms, or die from the H1N1pdm 2009 pandemic virus;Miller;PLoS Curr,2009

4. Antiviral agents for the treatment and chemoprophylaxis of influenza—recommendations of the Advisory Committee on Immunization Practices (ACIP);Fiore;MMWR Recomm Rep,2011

5. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses;Fu;Antiviral Res,2016

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