Multisite mpox infection and viral dynamics among persons with HIV in metro-Atlanta-Reference-Cited by-同舟云学术

Multisite mpox infection and viral dynamics among persons with HIV in metro-Atlanta

Published:2023-11-29 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Damhorst Gregory L¹²³^ORCID,Fujita A Wendy¹²^ORCID,Fitts Eric³⁴^ORCID,Szabo Brittany¹²^ORCID,Bowers Heather B³⁵⁶^ORCID,Sabino Courtney³⁵⁶,Ahmed Alaa⁷,Wang Ethan⁴,Piantadosi Anne¹⁴^ORCID,McLendon Kaleb⁴^ORCID,Sullivan Julie³⁵^ORCID,Greenleaf Morgan³^ORCID,McCaslin Divine²,Palmore Melody¹²,Anderson Albert M¹²,Aldred Bruce¹²^ORCID,Gunthel Clifford¹²^ORCID,Martin Greg S³⁸^ORCID,Colasanti Jonathan A¹²^ORCID,Lam Wilbur A³⁵⁹¹⁰^ORCID,Bassit Leda³⁵⁶^ORCID,Rao Anuradha³⁵^ORCID,Sheth Anandi N¹²^ORCID,Titanji Boghuma K¹²^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Emory University , Atlanta, GA , USA

2. The Ponce de Leon Center, Grady Health System , Atlanta, GA , USA

3. The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies , Atlanta, GA , USA

4. Department of Pathology and Laboratory Medicine, Emory University , Atlanta, GA , USA

5. Department of Pediatrics, Emory University School of Medicine , Atlanta, GA , USA

6. Laboratory of Biochemical Pharmacology, Emory University , Atlanta, GA , USA

7. Emory Integrated Genomics Core, Emory University , Atlanta, GA , USA

8. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University , Atlanta, GA USA

9. Aflac Cancer & Blood Disorders Center at Children’s Healthcare of Atlanta , Atlanta, GA , USA

10. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology , Atlanta, GA , USA

Abstract

Abstract The 2022 mpox outbreak primarily involved sexual transmission among men who have sex with men and disproportionately affected persons with HIV (PWH). We examined viral dynamics and clinical features in a cohort evaluated for mpox infection at a comprehensive HIV clinic in Atlanta, Georgia. Viral DNA was found in 8 oropharyngeal and 5 anorectal specimens among 10 mpox cases confirmed by lesion swab PCR. Within-participant anatomic site of lowest Ct value varied, and lower Ct values were found in oropharyngeal and anorectal swabs when corresponding symptoms were present. This provides insight into mpox infection across multiple anatomic sites among PWH.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiad530/53927231/jiad530.pdf

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Performance of the Xpert™ Mpox PCR assay with oropharyngeal, anorectal, and cutaneous lesion swab specimens;Journal of Clinical Virology;2024-04

2. Longitudinal Analysis of Mpox Virus DNA Detectability From Multiple Specimen Types During Acute Illness: A Cohort Study;Open Forum Infectious Diseases;2024-02-01