Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study-Reference-Cited by-同舟云学术

Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study

Published:2022-07-30 Issue:11 Volume:226 Page:1903-1908
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Vivaldi Giulia¹²^ORCID,Jolliffe David A¹²,Faustini Sian³,Shields Adrian M³,Holt Hayley¹²⁴,Perdek Natalia¹,Talaei Mohammad²^ORCID,Tydeman Florence¹²,Chambers Emma S¹,Cai Weigang¹,Li Wenhao¹,Gibbons Joseph M¹,Pade Corinna¹,McKnight Áine¹,Shaheen Seif O²,Richter Alex G³,Martineau Adrian R¹²⁴

Affiliation:

1. Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom

2. Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom

3. Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham , Birmingham , United Kingdom

4. Asthma UK Centre for Applied Research, Queen Mary University of London , London , United Kingdom

Abstract

Abstract In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72–.86]; P < .001) and S peptide–stimulated interferon-γ concentrations (rs = 0.31 [.13–.47]; P < .001).

Funder

Barts Charity

Rosetrees Trust and The Bloom Foundation

Rosetrees Trust

John Black Charitable Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac321/45415569/jiac321.pdf

Reference15 articles.