Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy-Reference-Cited by-同舟云学术

Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy

Published:2017-04-18 Issue:11 Volume:215 Page:1725-1733
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Gay Cynthia L.¹,Bosch Ronald J²,Ritz Justin²,Hataye Jason M.³,Aga Evgenia²,Tressler Randall L.⁴⁵,Mason Stephen W.⁶,Hwang Carey K.⁷,Grasela Dennis M.⁷,Ray Neelanjana⁷,Cyktor Josh C.⁸,Coffin John M.⁹,Acosta Edward P.¹⁰,Koup Richard A.³,Mellors John W.⁸,Eron Joseph J.¹,

Affiliation:

1. Department of Medicine, University of North Carolina at Chapel Hill;

2. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts;

3. Immunology Laboratory, Vaccine Research Center, and

4. Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland;

5. Columbus Technologies, El Segundo, California;

6. Bristol-Myers Squibb, Wallingford, Connecticut;

7. Bristol-Myers Squibb, Princeton, New Jersey;

8. Department of Medicine, University of Pittsburgh, Pennsylvania;

9. Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts;

10. Department of Pharmacology and Toxicology, University of Alabama School of Medicine, Birmingham

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/215/11/1725/23666975/jix191.pdf

Reference37 articles.

1. Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy;Palmer;Proc Natl Acad Sci U S A,2008

2. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction;Trautmann;Nat Med,2006

3. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection;Petrovas;J Exp Med,2006

4. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection;Blackburn;Nat Immunol,2009

5. T cell exhaustion;Wherry;Nat Immunol,2011

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