Bivalent Human Papillomavirus (HPV) Vaccine Effectiveness Correlates With Phylogenetic Distance From HPV Vaccine Types 16 and 18

Author:

Bogaards Johannes A12ORCID,van der Weele Pascal13,Woestenberg Petra J14,van Benthem Birgit H B1,King Audrey J1

Affiliation:

1. Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven

2. Department of Epidemiology and Biostatistics, Maastricht University Medical Centre, The Netherlands

3. Department of Pathology, Vrije Universiteit Amsterdam, Amsterdam University Medical Centres, Maastricht University Medical Centre, The Netherlands

4. Care and Public Health Research Institute, Maastricht University Medical Centre, The Netherlands

Abstract

Abstract To substantiate cross-protection reported across AS04-adjuvanted bivalent human papillomavirus (HPV) vaccine (2vHPV) studies, we reevaluated vaccine effectiveness against type-specific HPV positivity as a function of phylogenetic distance to vaccine target types HPV-16 and -18. We provide evidence of sustained cross-protection up to 8 years postvaccination in a high-risk population in the Netherlands. Moreover, our findings suggest that genomic distance better explains cross-protection than distance measures based on capsid antigens only. Taken together, 2vHPV is predicted to provide partial cross-protection against HPV-31, -33, -35, -45, -52, and possibly -58, that is, acknowledged oncogenic types with close phylogenetic relationships to HPV-16 or -18.

Funder

Dutch Ministry of Health, Welfare and Sport

National Institute for Public Health and the Environment

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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