Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication

Author:

di Masi Alessandra1,Leboffe Loris1,Polticelli Fabio12,Tonon Federica3,Zennaro Cristina3,Caterino Marianna45,Stano Pasquale1,Fischer Stephan6,Hägele Marlen7,Müller Martin7,Kleger Alexander7,Papatheodorou Panagiotis68,Nocca Giuseppina910,Arcovito Alessandro9,Gori Andrea11,Ruoppolo Margherita4512,Barth Holger6,Petrosillo Nicola13,Ascenzi Paolo1,Di Bella Stefano13

Affiliation:

1. Department of Sciences, Roma Tre University, Roma, Italy

2. National Institute of Nuclear Physics, Roma Tre Section, Roma, Italy

3. Department of Medical, Surgery and Health Sciences, University of Trieste, Trieste, Italy

4. Department of Molecular Medicine and Medical Biotechnology, University of Napoli “Federico II”, Napoli, Italy

5. Associazione Culturale DiSciMuS RCF, Casoria, Napoli, Italy

6. Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany

7. Department of Internal Medicine I, University of Ulm Medical Center, Germany

8. Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Freiburg, Germany

9. Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Heart, Roma, Italy

10. Institute of Chemistry of Molecular Recognition, CNR, Roma, Italy

11. Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy

12. CEINGE Biotecnologie Avanzate, Napoli, Italy

13. 2nd Infectious Diseases Division, National Institute for Infectious Diseases “L. Spallanzani”, Roma, Italy

Funder

Roma Tre University

PharmCompNetWork Baden-Württemberg

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference41 articles.

1. Multistate point-prevalence survey of health care-associated infections;Magill;N Engl J Med,2014

2. Clinical recognition and diagnosis of Clostridium difficile infection;Bartlett;Clin Infect Dis,2008

3. Clostridium difficile infection;Leffler;N Engl J Med,2015

4. Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection;Walker;Clin Infect Dis,2013

5. Temporal changes in serum albumin and total protein in patients with hospital-acquired Clostridium difficile infection;Kumarappa;Ann Clin Lab Sci,2014

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