Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19
Author:
Jensen Tomas O1ORCID, Grandits Greg A2, Jain Mamta K3ORCID, Murray Thomas A2, Grund Birgit4, Shaw-Saliba Kathryn5, Matthay Michael A6, Abassi Mahsa7ORCID, Ardelt Magdalena6, Baker Jason V78, Chen Peter9, Dewar Robin L10, Goodman Anna L1112, Hatlen Timothy J13, Highbarger Helene C10, Holodniy Mark1415ORCID, Lallemand Perrine10, Laverdure Sylvain16, Leshnower Bradley G17, Looney David18, Moschopoulos Charalampos D19, Mugerwa Henry20, Murray Daniel D1, Mylonakis Eleftherios21ORCID, Nagy-Agren Stephanie2223, Rehman M Tauseef10, Rupert Adam10, Stevens Randy A10, Turville Stuart24, Weintrob Amy25, Wick Katherine26, Lundgren Jens1ORCID, Ko Emily R27, Sahner David, Tierney John, Vogel Susan E, Herpin Betsey R, Smolskis Mary C, McKay Laura A, Cahill Kelly, Crew Page, Sardana Ratna, Raim Sharon Segal, Hensely Lisa, Lorenzo Johsua, Mock Rebecca, Zuckerman Judith, Atri Negin, Miller Mark, Vallee David, Chung Lucy, Kang Nayon, Barrett Kevin, Adam Stacey J, Read Sarah, Draghia-Akli Ruxandra, Currier Judy, Hughes Eric, Harrigan Rachel H, Amos Laura, Carlsen Amy, Carter Anita, Collins Gary, Davis Bionca, Denning Eileen, DuChene Alain, Eckroth Kate, Engen Nicole, Frase Alex, Gandits Greg, Grund Birgit, Harrison Merrie, Hurlbut Nancy, Kaiser Payton, Koopmeiners Joseph, Larson Gregg, Meger Sue, Mistry Shweta Sharma, Murray Thomas, Nelson Ray, Quan Kien, Quan Siu Fun, Reilly Cavan, Siegel Lianne, Thompson Greg, Vock David, Walski Jamie, Gelijns Annetine C, Moskowitz Alan J, Bagiella Emilia, Moquete Ellen, O'Sullivan Karen, Marks Mary E, Accardi Evan, Kinzel Emily, Burris Sarah, Bedoya Gabriela, Gupta Lola, Overbey Jessica R, Santos Milerva, Gillinov Marc A, Miller Marissa A, Taddei-Peters Wendy C, Fenton Kathleen, Sandkovsky Uriel, Gottlieb Robert L, Mack Michael, Berhe Mezgebe, Haley Clinton, Dishner Emma, Bettacchi Christopher, Golden Kevin, Duhaime Erin, Ryan Madison, Burris Sarah, Tallmadge Catherine, Estrada Lorie, Jones Felecia, Villa Samatha, Wang Samatha, Robert Raven, Coleman Tanquinisha, Clariday Laura, Baker Rebecca, Hurutado-Rodriguez Mariana, Iram Nazia, Fresnedo Michelle, Davis Allyson, Leonard Kiara, Ramierez Noelia, Thammavong Jon, Duque Krizia, Turner Emma, Fisher Tammy, Robinson Dianna, Ransom Desirae, Maldonado Nicholas, Lusk Erica, Killian Aaron, Palacious Adriana, Solis Edilia, Jerrow Janet, Watts Matthew, Whitacre Heather, Cothran Elizabeth, Smith Peter K, Barkauskas Christina E, Vekstein Andrew M, Ko Emily R, Dreyer Grace R, Stafford Neil, Brooks Megan, Der Tatyana, Witte Marie, Gamarallage Ruwan, Franzone John, Ivey Noel, Lumsden Rebecca H, Mosaly Nilima, Mourad Ahmaad, Holland Thomas L, Motta Mary, Lane Kathleen, McGowan Lauren M, Stout Jennifer, Aloor Heather, Bragg Kennesha M, Toledo Barvina, McLendon-Arvik Beth, Bussadori Barbara, Hollister Beth A, Griffin Michelle, Giangiacomo Dana M, Rodriguez Vicente, Bokhart Gordon, Eichman Sharon M, Parrino Patrick E, Spindel Stephen, Bansal Aditya, Baumgarten Katherine, Hand Johnathan, Vonderhaar Derek, Nossaman Bobby, Laudun Sylvia, Ames DeAnna, Broussard Shane, Hernandez Nilmo, Isaac Geralyn, Dinh Huan, Zheng Yiling, Tran Sonny, McDaniel Hunter, Crovetto Nicolle, Perin Emerson, Costello Briana, Manian Prasad, Sohail M Rizwan, Postalian Alexander, Hinsu Punit, Watson Carolyn, Chen James, Fink Melyssa, Sturgis Lydia, Walker Kim, Mahon Kim, Parenti Jennifer, Kappenman Casey, Knight Aryn, Sturek Jeffrey M, Barros Andrew, Enfield Kyle B, Kadl Alexandra, Green China J, Simon Rachel M, Fox Ashley, Thornton Kara, Adams Amy, Badhwar Vinay, Sharma Sunil, Peppers Briana, McCarthy Paul, Krupica Troy, Sarwari Arif, Reece Rebecca, Fornaresico Lisa, Glaze Chad, Evans Raquel, Di Fang, Carlson Shawn, Aucremanne Tanja, Tennant Connie, Giblin Sutton Lisa, Buterbaugh Sabrina, Williams Roger, Bunner Robin, Traverse Jay H, Rhame Frank, Huelster Joshua, Kethireddy Rajesh, Davies Irena, Salamanca Julianne, Majeski Christine, Skelton Paige, Zarambo Maria, Sarafolean Andrea, Bowdish Michael E, Borok Zea, Wald-Dickler Noah, Hutcheon Douglass, Towfighi Amytis, Lee Mary, Lewis Meghan R, Spellberg Brad, Sher Linda, Sharma Aniket, Olds Anna P, Justino Chris, Loxano Edward, Romero Chris, Leong Janet, Rodina Valentina, Quesada Christine, Hamilton Luke, Escobar Jose, Leshnower Brad, Bender William, Sharifpour Milad, Miller Jeffrey, Farrington Woodrow, Baio Kim T, McBride Mary, Fielding Michele, Mathewson Sonya, Porte Kristina, Maton Missy, Ponder Chari, Haley Elisabeth, Spainhour Christine, Rogers Susan, Tyler Derrick, Madathil Ronson J, Rabin Joseph, Levine Andrea, Saharia Kapil, Tabatabai Ali, Lau Christine, Gammie James S, Peguero Maya-Loren, McKernan Kimberly, Audette Mathew, Fleischmann Emily, Akbari Kreshta, Lee Myounghee, Chi Andrew, Salehi Hanna, Pariser Alan, Nyguyen Phuong Tran, Moore Jessica, Gee Adrienne, Vincent Shelika, Zuckerman Richard A, Iribarne Alexander, Metzler Sara, Shipman Samantha, Johnson Haley, Newton Crystallee, Parr Doug, Miller Leslie, Schelle Beth, McLean Sherry, Rothbaum Howard R, Alvarez Michael S, Kalan Shivam P, Germann Heather H, Hendershot Jennifer, Moroney Karen, Herring Karen, Cook Sharri, Paul Pam, Walker-Ignasiak Rebecca, North Crystal, Oldmixon Cathryn, Ringwood Nancy, Muzikansky Ariela, Morse Richard, Fitzgerald Laura, Morin Haley D, Brower Roy G, Reineck Lora A, Bienstock Karen, Steingrub Jay H, Hou Peter K, Steingrub Jay S, Tidswell Mark A, Kozikowski Lori-Ann, Kardos Cynthia, DeSouza Leslie, Romain Sarah, Thornton-Thompson Sherell, Talmor Daniel, Shapiro Nathan, Andromidas Konstantinos, Banner-Goodspeed Valerie, Bolstad Michael, Boyle Katherine L, Cabrera Payton, deVilla Arnaldo, Ellis Joshua C, Grafals Ana, Hayes Sharon, Higgins Conor, Kurt Lisa, Kurtzman Nicholas, Redman Kimberly, Rosseto Elinita, Scaffidi Douglas, Shapiro Nathan, Filbin Michael R, Hibbert Kathryn A, Parry Blair, Margolin Justin, Hillis Brooklynn, Hamer Rhonda, Brait Kelsey, Beakes Caroline, McKaig Brenna, Kugener Eleonore, Jones Alan E, Galbraith James, Nandi Utsav, Peacock Rebekah, Hendey Gregory, Kangelaris Kirsten, Ashktorab Kimia, Gropper Rachel, Agrawal Anika, Yee Kimberley J, Jauregui Alejandra E, Zhuo Hanjing, Almasri Eyad, Fayed Mohamed, Hubel Kinsley A, Hughes Alyssa R, Garcia Rebekah L, Lim George W, Chang Steven Y, Hendey Gregory, Lin Michael Y, Vargas Julia, Sihota Hena, Beutler Rebecca, Agarwal Trisha, Wilson Jennifer G, Vojnik Rosemary, Perez Cynthia, McDowell Jordan H, Roque Jonasel, Wang Henry, Huebinger Ryan M, Patel Bela, Vidales Elizabeth, Albertson Timothy, Hardy Erin, Harper Richart, Moss Marc A, Baduashvili Amiran, Chauhan Lakshmi, Douin David J, Martinez Flora, Finck Lani L, Bastman Jill, Howell Michelle, Higgins Carrie, McKeehan Jeffrey, Finigan Jay, Stubenrauch Peter, Janssen William J, Griesmer Christine, VerBurg Olivia, Hyzy Robert C, Park Pauline K, Nelson Kristine, McSparron Jake I, Co Ivan N, Wang Bonnie R, Jimenez Jose, Olbrich Norman, McDonough Kelli, Jia Shijing, Hanna Sinan, Gong Michelle N, Richardson Lynne D, Nair Rahul, Lopez Brenda, Amosu Omowunmi, Offor Obiageli, Tzehaie Hiwet, Nkemdirim William, Boujid Sabah, Mosier Jarrod M, Hypes Cameron, Campbell Elizabeth Salvagio, Bixby Billie, Gilson Boris, Lopez Anitza, Bime Christian, Parthasarathy Sairam, Cano Ariana M, Hite R Duncan, Terndrup Thomas E, Wiedemann Herbert P, Hudock Kristin, Tanzeem Hammad, More Harshada, Martinkovic Jamie, Sellers Susan, Houston Judy, Burns Mary, Kiran Simra, Roads Tammy, Kennedy Sarah, Duggal Abhijit, Thiruchelvam Nirosshan, Ashok Kiran, King Alexander H, Mehkri Omar, Dugar Siddharth, Sahoo Debasis, Yealy Donald M, Angus Derek C, Weissman Alexandra J, Vita Tina M, Berryman Emily, Hough Catherine L, Khan Akram, Krol Olivia F, Mills Emmanuel, Kinjal Mistry, Briceno Genesis, Reddy Raju, Hubel Kinsley, Jouzestani Milad K, McDougal Madeline, Deshmukh Rupali, Johnston Nicholas J, Robinson Bryce H, Gundel Staphanie J, Katsandres Sarah C, Chen Peter, Torbati Sam S, Parimon Tanyalak, Caudill Antonina, Mattison Brittany, Jackman Susan E, Chen Po-En, Bayoumi Emad, Ojukwu Cristabelle, Fine Devin, Weissberg Gwendolyn, Isip Katherine, Choi-Kuaea Yunhee, Mehdikhani Shaunt, Dar Tahir B, Augustin Nsole Biteghe Fleury, Tran Dana, Dukov Jennifer Emilow, Matusov Yuri, Choe June, Hindoyan Niree A, Wynter Timothy, Pascual Ethan, Clapham Gregg J, Herrera Lisa, Caudill Antonia, O'Mahony D Shane, Nyatsatsang Sonam T, Wilson David M, Wallick Julie A, Duven Alexandria M, Fletcher Dakota D, Miller Chadwick, Files D Clark, Gibbs Kevin W, Flores Lori S, LaRose Mary E, Landreth Leigha D, Palacios D Rafael, Parks Lisa, Hicks Madeline, Goodwin Andrew J, Kilb Edward F, Lematty Caitlan T, Patti Kerilyn, Grady Abigail, Rasberry April, Morris Peter E, Sturgill Jamie L, Cassity Evan P, Dhar Sanjay, Montgomery-Yates Ashley A, Pasha Sarah N, Mayer Kirby P, Bissel Brittany, Trott Terren, Rehman Shahnaz, de Wit Marjolein, Mason Jessica, Bledsoe Joseph, Knowlton Kirk U, Brown Samuel, Lanspa Michael, Leither Lindsey, Pelton Ithan, Armbruster Brent P, Montgomery Quinn, Kumar Naresh, Fergus Melissa, Imel Karah, Palmer Ghazal, Webb Brandon, Klippel Carolyn, Jensen Hannah, Duckworth Sarah, Gray Andrew, Burke Tyler, Knox Dan, Lumpkin Jenna, Aston Valerie T, Applegate Darrin, Serezlic Erna, Brown Katie, Merril Mardee, Harris Estelle S, Middleton Elizabeth A, Barrios Macy A G, Greer Jorden, Schmidt Amber D, Webb Melissa K, Paine Roert, Callahan Sean J, Waddoups Lindsey J, Yamane Misty B, Self Wesley H, Rice Todd W, Casey Jonathan D, Johnson Jakea, Gray Christopher, Hays Margaret, Roth Megan, Menon Vidya, Kasubhai Moiz, Pillai Anjana, Daniel Jean, Sittler Daniel, Kanna Balavenkatesh, Jilani Nargis, Amaro Francisco, Santana Jessica, Lyakovestsky Aleksandr, Madhoun Issa, Desroches Louis Marie, Amadon Nicole, Bahr Alaa, Ezzat Imaan, Guerrero Maryanne, Padilla Joane, Fullmer Jessie, Singh Inderpreet, Shah Syed Hamad Ali, Narang Rajeev, Mock Polly, Shadle Melissa, Hernandez Brenda, Welch Kevin, 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Meegada Sreenath, Koripalli VenkataSandeep, Muddana Prithvi, Jain Lakshay, Undavalli Chaitanya, Kavya Parasa, Ibiwoye Mofoluwaso, Akilo Hameed, Lovette Bryce D, Wylie Jamie-Crystal, Smith Diana M, Poon Kenneth, Eckardt Paula, Heysu Rubio-Gomez, Sundararaman Nithya, Alaby Doris, Sareli Candice, Sánchez Adriana, Popielski Laura, Kambo Amy, Viens Kimberley, Turner Melissa, Vjecha Michael J, Weintrob Amy, Brar Indira, Markowitz Norman, Pastor Erika, Corpuz Roweena, Alangaden George, McKinnon John, Ramesh Mayur, Herc Erica, Yared Nicholas, Abreu Lanfranco Odaliz, Rivers Emanuel, Swiderek Jennifer, Hodari Gupta Ariella, Pabla Pardeep, Eliya Sonia, Jazrawi Jehan, Delor Jeremy, Desai Mona, Cook Aaron, Kathrina Jaehne Anja, Kaur Gill Jasreen, Renaud Sheri, Sarveswaran Siva, Gardner Edward, Scott James, Bianchini Monica, Melvin Casey, Kim Gina, Wyles David, Kamis Kevin, Miller Rachel, Douglas Ivor, Haukoos Jason, Hicks Carrie, Lazarte Susana, Marines-Price Rubria, Osuji Alice, Agbor Barbine Tchamba Agbor, Petersen Tianna, Kamel Dena, Hansen Laura, Garcia Angie, Cha Christine, Mozaffari Azadeh, Hernandez Rosa, Cutrell James, Agbor Barbine Tchamba Agbor, Kim Mina, DellaValle Natalie, Gonzales Sonia, Somboonwit Charurut, Oxner Asa, Guerra Lucy, Hayes Michael, Nguyen Thi, Tran Thanh, Pinto Avenette, Hatlen Timothy, Anderson Betty, Zepeda-Gutierrez Ana, Martin Dannae, Temblador Cindi, Cuenca Avon, Tanoviceanu Roxanne, Prieto Martha, Guerrero Mario, Martin Dannae, Daar Eric, Correa Ramiro, Hartnell Gabe, Wortmann Glenn, Doshi Saumil, Moriarty Theresa, Gonzales Melissa, Garman Kristin, Baker Jason V, Frosch Anne, Goldsmith Rachael, Driver Brian, Frank Christine, Leviton Tzivia, Prekker Matthew, Jibrell Hodan, Lo Melanie, Klaphake Jonathan, Mackedanz Shari, Ngo Linh, Garcia-Myers Kelly, Kunisaki Ken M, Wendt Chris, Melzer Anne, Wetherbee Erin, Drekonja Dimitri, Pragman Alexa, Hamel Aimee, Thielen Abbie, Kunisaki Ken M, Hassler Miranda, Walquist Mary, Augenbraun Michael, George Jensen, Demeo Lynette, Mishko Motria, Thomas Lorraine, Tatem Luis, Dehovitz Jack, Abassi Mahsa, Leuck Anne-Marie, Rao Via, Pullen Matthew, Luke Darlette, LaBar Derek, Christiansen Theresa, Howard Diondra, Biswas Kousick, Harrington Cristin, Garcia Amanda, Bremer Tammy, Burke Tara, Koker Brittany, Davis-Karim Anne, Pittman David, Vasudeva Shikha S, Johnstone Jaylynn R, Agnetti Kate, Davis Ruby, Trautner Barbara, Hines-Munson Casey, Van John, Dillon Laura, Wang Yiqun, Nagy-Agren Stephanie, Vasudeva Shikha, Ochalek Tracy, Caldwell Erin, Humerickhouse Edward, Boone David, McGraw William, Looney David J, Mehta Sanjay R, Johns Scott Thompson, St John Melissa, Raceles Jacqueline, Sear Emily, Funk Stephen, Cesarini Rosa, Fang Michelle, Nicalo Keith, Drake Wonder, Jones Beatrice, Holtman Teresa, Nguyen Hien H, Maniar Archana, Johnson Eric A, Nguyen Lam, Tran Michelle T, Barrett Thomas W, Johnston Tera, Huggins John T, Beiko Tatsiana Y, Hughes Heather Y, McManigle William C, Tanner Nichole T, Washburn Ronald G, Ardelt Magdalena, Tuohy Patricia A, Mixson Jennifer L, Hinton Charles G, Thornley Nicola, Allen Heather, Elam Shannon, Boatman Barry, Baber Brittany J, Ryant Rudell, Roller Brentin, Nguyen Chinh, Mikail Amani Morgan, Hansen Marivic, Lichtenberger Paola, Baracco Gio, Ramos Carol, Bjork Lauren, Sueiro Melyssa, Tien Phyllis, Freasier Heather, Buck Theresa, Nekach Hafida, Holodniy Mark, Chary Aarthi, Lu Kan, Peters Theresa, Lopez Jessica, Tan Susanna Yu, Lee Robert H, Asghar Aliya, Isip Tasadduq Karim Karyn, Le Katherine, Nguyen Thao, Wong Shinn, Raben Dorthe, Murray Daniel D, Jensen Tomas O, Peters Lars, Aagaard Bitten, Nielsen Charlotte B, Krapp Katharina, Nykjær Bente Rosdahl, Olsson Christina, Kanne Katja Lisa, Grevsen Anne Louise, Joensen Zillah Maria, Bruun Tina, Bojesen Ane, Woldbye Frederik, Normand Nick E, Esman Frederik V L, Benfield Thomas, Clausen Clara Lundetoft, Hovmand Nichlas, Israelsen Simone Bastrup, Iversen Katrine, Leding Caecilie, Pedersen Karen Brorup, Thorlacius-Ussing Louise, Tinggaard Michaela, Tingsgard Sandra, Krohn-Dehli Louise, Pedersen Dorthe, Villadsen Signe, Jensen Jens-Ulrik Staehr, Overgaard Rikke, Rastoder Ema, Heerfordt Christian, Hedsund Caroline, Ronn Christian Phillip, Kamstrup Peter Thobias, Hogsberg Dorthe Sandbaek, Bergsoe Christina, Søborg Christian, Hissabu Nuria M S, Arp Bodil C, Ostergaard Lars, Staerke Nina Breinholt, Yehdego Yordanos, Sondergaard Ane, Johansen Isik S, Arnholdt Pedersen Andreas, Knudtzen Fredrikke C, Larsen Lykke, Hertz Mathias A, Fabricius Thilde, Holden Inge K, Lindvig Susan O, Helleberg Marie, Gerstoft Jan, Kirk Ole, Bruun Tina, Jensen Tomas Ostergaard, Madsen Birgitte Lindegaard, Pedersen Thomas Ingemann, Harboe Zitta Barrella, Roge Birgit Thorup, Hansen Thomas Michael, Glesner Matilde Kanstrup, Lofberg Sandra Valborg, Nielsen Ariella Denize, Leicht von Huth Sebastian, Nielsen Henrik, Thisted Rikke Krog, Petersen Kristine Toft, Juhl Maria Ruwald, Podlekareva Daria, Johnsen Stine, Andreassen Helle Frost, Pedersen Lars, Lindnér Cecilia Ebba Clara Ellinor, Wiese Lothar, Knudsen Lene Surland, Nytofte Nikolaj Julian Skrøder, Havmøller Signe Ravn, Expósito Maria, Badillo José, Martínez Ana, Abad Elena, Chamorro Ana, Figuerola Ariadna, Mateu Lourdes, España Sergio, Lucero Maria Constanza, Santos José Ramón, Lladós Gemma, Lopez Cristina, Carabias Lydia, Molina-Morant Daniel, Loste Cora, Bracke Carmen, Siles Adrian, Fernández-Cruz Eduardo, Natale Marisa Di, Padure Sergiu, Gomez Jimena, Ausin Cristina, Cervilla Eva, Balastegui Héctor, Sainz Carmen Rodríguez, Lopez Paco, Carbone Javier, Escobar Mariam, Balerdi Leire, Legarda Almudena, Roldan Montserrat, Letona Laura, Muñoz José, Camprubí Daniel, Arribas Jose R, Sánchez Rocio Montejano, Díaz-Pollán Beatriz, Stewart Stefan Mark, Garcia Irene, Borobia Alberto, Mora-Rillo Marta, Estrada Vicente, Cabello Noemi, Nuñez-Orantos M J, Sagastagoitia I, Homen J R, Orviz E, Montalvá Adrián Sánchez, Espinosa-Pereiro Juan, Bosch-Nicolau Pau, Salvador Fernando, Burgos Joaquin, Morales-Rull Jose Luis, Pena Anna Maria Moreno, Acosta Cristina, Solé-Felip Cristina, Horcajada Juan P, Sendra Elena, Castañeda Silvia, López-Montesinos Inmaculada, Gómez-Junyent Joan, Gonzáles Carlota Gudiol, Cuervo Guilermo, Pujol Miquel, Carratalà Jordi, Videla Sebastià, Günthard Huldrych, Braun Dominique L, West Emily, M'Rabeth-Bensalah Khadija, Eichinger Mareile L, Grüttner-Durmaz Manuela, Grube Christina, Zink Veronika, Goes Josefine, Fätkenheuer Gerd, Malin Jakob J, Tsertsvadze Tengiz, Abutidze Akaki, Chkhartishvili Nikoloz, Metchurtchlishvili Revaz, Endeladze Marina, Paciorek Marcin, Bursa Dominik, Krogulec Dominika, Pulik Piotr, Ignatowska Anna, Horban Andrzej, Bakowska Elzbieta, Kowaska Justyna, Bednarska Agnieszka, Jurek Natalia, Skrzat-Klapaczynska Agata, Bienkowski Carlo, Hackiewicz Malgorzata, Makowiecki Michal, Platowski Antoni, Fishchuk Roman, Kobrynska Olena, Levandovska Khrystyna, Kirieieva Ivanna, Kuziuk Mykhailo, Naucler Pontus, Perlhamre Emma, Mazouch Lotta, Kelleher Anthony, Polizzotto Mark, Carey Catherine, Chang Christina C, Hough Sally, Virachit Sophie, Davidson Sarah, Bice Daniel J, Ognenovska Katherine, Cabrera Gesalit, Flynn Ruth, Young Barnaby E, Chia Po Ying, Lee Tau Hong, Lin Ray J, Lye David C, Ong Sean W X, Puah Ser Hon, Yeo Tsin Wen, Diong Shiau Hui, Ongko Juwinda, Yeo He Ping, Eriobu Nnakelu, Kwaghe Vivian, Zaiyad Habib, Idoko Godwin, Uche Blessing, Selvamuthu Poongulali, Kumarasamy Nagalingeswaran, Beulah Faith Ester, Govindarajan Narayan, Mariyappan Kowsalya, Losso Marcelo H, Abela Cecilia, Moretto Renzo, Belloc Carlos G, Ludueña Jael, Amar Josefina, Losso Marcelo H, Toibaro Javier, Macias Laura Moreno, Fernandez Lucia, Frare Pablo S, Chaio Sebastian R, Pachioli Valeria, Timpano Stella M, Sanchez Marisa del Lujan, Sierra Mariana de Paz, Stanek Vanina, Belloso Waldo, Cilenti Flavia L, Valentini Ricardo N, Stryjewski Martin E, Locatelli Nicolas, Soler Riera Maria C, Salgado Clara, Baeck Ines M, Di Castelnuovo Valentina, Zarza Stella M, Hudson Fleur, Parmar Mahesh K B, Goodman Anna L, Badrock Jonathan, Gregory Adam, Goodall Katharine, Harris Nicola, Wyncoll James, Bhagani S, Rodger A, Luntiel A, Patterson C, Morales J, Witele E, Preston A M, Nandani A, Price D A, Hanrath Aiden, Nell Jeremy, Patel Bijal, Hays Carole, Jones Geraldine, Davidson Jade, Goodman Anna L, Bawa T, Mathews M, Mazzella A, Bisnauthsing K, Aguilar-Jimenez L, Borchini F, Hammett S, Touloumi Giota, Pantazis Nikos, Gioukari Vicky, Souliou Tania, Antoniadou A, Protopapas K, Kavatha D, Grigoropoulou S, Tziolos R N, Oikonomopoulo C, Moschopoulos C, Koulouris N G, Tzimopoulos K, Koromilias A, Argyraki K, Lourida P, Bakakos P, Kalomenidis I, Vlachakos V, Barmparessou Z, Balis E, Zakynthinos S, Sigala I, Gianniou N, Dima E, Magkouta S, Synolaki E, Konstanta S, Vlachou M, Stathopoulou P, Panagopoulos P, Petrakis V, Papazoglou D, Tompaidou E, Isaakidou E, Poulakou G, Rapti V, Leontis K, Nitsotolis T, 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Rupert Adam W, Baseler Michael, Lynam Danielle, Imamichi Tom, Laverdure Sylvain, McCormack Ashley, Paudel Sharada, Cook Kyndal, Haupt Kendra, Khan Ayub, Hazen Allison, Badralmaa Yunden, Smith Kenneth, Patel Bhakti, Kubernac Amanda, Kubernac Robert, Hoover Marie L, Solomon Courtney, Rashid Marium, Murphy Joseph, Brown Craig, DuChateau Nadine, Ellis Sadie, Flosi Adam, Fox Lisa, Johnson Les, Nelson Rich, Stojanovic Jelena, Treagus Amy, Wenner Christine, Williams Richard,
Affiliation:
1. Centre of Excellence for Health, Immunity, and Infections, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark 2. Division of Biostatistics, University of Minnesota , Minneapolis, Minnesota , USA 3. Southwestern Medical Center, University of Texas , Dallas, Texas USA 4. School of Statistics, University of Minnesota , Minneapolis, Minnesota , USA 5. National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA 6. Division of Pulmonary and Critical Care Medicine, University of California SanFrancisco , San Francisco, California , USA 7. Division of Infectious Diseases and International Medicine, University of Minnesota , Minneapolis, Minnesota , USA 8. Division of Infectious Diseases, Hennepin Healthcare , Minneapolis, Minnesota , USA 9. Women's Guild Lung Institute, Department of medicine and Biomedical Sciences, Cedars-Sinai Medical Center , Los Angeles, California , USA 10. Frederick National Laboratory for Cancer Research , Frederick, Maryland , USA 11. Medical Research Council Clinical Trials Unit, University College London , London , United Kingdom 12. Department of Infectious Diseases, Guy's and St Thomas’ National Health Service Foundation Trust , London , United Kingdom 13. Lundquist Institute, Harbor-University of California Los Angeles Medical Center , Torrance, California , USA 14. Department of Medicine, Infectious Diseases, Stanford University , Stanford, California , USA 15. Veterans Affairs Palo Alto Health Care System , Palo Alto, California , USA 16. Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research , Frederick, Maryland , USA 17. Division of Cardiothoracic Surgery, Emory School of Medicine , Atlanta, Georgia , USA 18. Division of Infectious Diseases and Global Public Health, University of California San Diego , San Diego, California , USA 19. School of Medicine, National and Kapodistrian University of Athens , Athens , Greece 20. Joint Clinical Research Centre , Kampala , Uganda 21. Department of Medicine, Houston Methodist Hospital , Houston, Texas , USA 22. Salem Veterans Affairs Medical Center , Virginia , USA 23. Virginia Tech Carilion School of Medicine , Virginia , USA 24. The Kirby Institute , University of New South Wales, Sydney , Australia 25. Infectious Diseases Section, Washington DC Veterans Affairs Medical Center , Washington, District of Columbia , USA 26. Department of Internal Medicine, University of California Davis , Davis, California , USA 27. Division of General Internal Medicine, Department of Medicine, Duke University Health System , Durham, North Carolina , USA
Abstract
Abstract
Background
Neutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood.
Methods
Participants enrolled in the Therapeutics for Inpatients with COVID-19 trials were randomized to nmAb versus placebo. Longitudinal differences between treatment and placebo groups in levels of plasma nucleocapsid antigen (N-Ag), anti-nucleocapsid antibody, C-reactive protein, interleukin-6, and d-dimer at enrollment, day 1, 3, and 5 were estimated using linear mixed models. A 7-point pulmonary ordinal scale assessed at day 5 was compared using proportional odds models.
Results
Analysis included 2149 participants enrolled between August 2020 and September 2021. Treatment resulted in 20% lower levels of plasma N-Ag compared with placebo (95% confidence interval, 12%–27%; P < .001), and a steeper rate of decline through the first 5 days (P < .001). The treatment difference did not vary between subgroups, and no difference was observed in trajectories of other biomarkers or the day 5 pulmonary ordinal scale.
Conclusions
Our study suggests that nmAb has an antiviral effect assessed by plasma N-Ag among hospitalized patients with COVID-19, with no blunting of the endogenous anti-nucleocapsid antibody response. No effect on systemic inflammation or day 5 clinical status was observed.
Clinical Trials Registration
NCT04501978.
Funder
National Institute of Allergy and Infectious Diseases National Cancer Institute
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Immunology and Allergy
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