HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

Author:

Benner Sarah E1,Zhu Xianming1,Hussain Sarah2,Florman Sander3,Eby Yolanda1,Fernandez Reinaldo E2,Ostrander Darin2,Rana Meenakshi4,Ottmann Shane5,Hand Jonathan6,Price Jennifer C7,Pereira Marcus R8,Wojciechowski David9,Simkins Jacques10,Stosor Valentina11,Mehta Sapna A12,Aslam Saima13,Malinis Maricar14ORCID,Haidar Ghady15ORCID,Massie Allan16,Smith Melissa L17,Odim Jonah18,Morsheimer Megan18,Quinn Thomas C219,Laird Gregory M20,Siliciano Robert2,Balagopal Ashwin2,Segev Dorry L16,Durand Christine M2,Redd Andrew D219,Tobian Aaron A R12ORCID

Affiliation:

1. Department of Pathology, Johns Hopkins School of Medicine , Baltimore, Maryland , USA

2. Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine , Baltimore, Maryland , USA

3. Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai , New York, New York , USA

4. Department of Medicine, Icahn School of Medicine at Mount Sinai , New York, New York , USA

5. Department of Surgery, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

6. Department of Infectious Diseases, Ochsner Health , New Orleans, Louisiana , USA

7. Department of Medicine, University of California San Francisco , San Francisco, California , USA

8. Department of Medicine, Columbia University Irving Medical Center , New York, New York , USA

9. Division of Nephrology, University of Texas Southwestern , Dallas, Texas , USA

10. Department of Medicine/Division of Infectious Diseases, University of Miami School of Medicine , Miami, Florida , USA

11. Departments of Medicine and Surgery, Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA

12. Department of Medicine, New York University Grossman School of Medicine, New York University Langone Health , New York, New York , USA

13. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego , La Jolla, California , USA

14. Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut , USA

15. Department of Medicine, Division of Infectious Diseases, University of Pittsburgh , Pittsburgh, Pennsylvania , USA

16. Department of Surgery, New York University Grossman School of Medicine, New York University Langone Health , New York, New York , USA

17. Department of Biochemistry and Molecular Genetics, University of Louisville , Louisville, Kentucky , USA

18. Division of Extramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

19. Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

20. Accelevir Diagnostics , Baltimore, Maryland , USA

Abstract

Abstract The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes, Digestive and Kidney Diseases

Division of Intramural Research

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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