Affiliation:
1. Department of Nutritional Sciences and Dietetics, International Hellenic University (IHU), Thessaloniki, Greece
2. Medical School, Aristotle University, Thessaloniki, Greece
Abstract
ABSTRACT
During the last 30 y, a gluten-free diet has been classified among the most popular fad diets mainly due to the ambiguous notion that gluten avoidance promotes health. Gluten intolerance has been implicated in non-celiac gluten sensitivity (NCGS) and irritable bowel syndrome (IBS), 2 disorders with overlapping symptoms and increasing trend. Together with gluten, other wheat components; fermentable oligo-, di-, monosaccharide, and polyols (FODMAPs); and amylase trypsin inhibitors (ATIs), are implicated in the pathogenesis of both disorders. Gut microflora alterations in IBS and NCGS have been described, while microbiota manipulations have been shown to be promising in some IBS cases. This literature review summarizes our current knowledge on the impact of wheat ingredients (gluten, FODMAPs, and ATIs) in IBS and NCGS. In both disorders, FODMAPs and ATIs trigger gut dysbiosis, suggesting that gluten may not be the culprit, and microbiota manipulations can be applied in diagnostic and intervention approaches.
Publisher
Oxford University Press (OUP)
Subject
Nutrition and Dietetics,Food Science,Medicine (miscellaneous)
Reference106 articles.
1. Spectrum of gluten-related disorders: consensus on new nomenclature and classification;Sapone,2012.
2. Health benefits and adverse effects of a gluten-free diet in non-celiac disease patients;Niland;Gastroenterol Hepatol,2018
3. Randomised clinical trial: gluten may cause depression in subjects with non-coeliac gluten sensitivity—an exploratory clinical study;Peters;Aliment Pharmacol Ther,2014
4. Gut microbiota role in irritable bowel syndrome: new therapeutic strategies;Distrutti;World J Gastroenterol,2016
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献