Application of Organoids in Regenerative Medicine-Reference-Cited by-同舟云学术

Application of Organoids in Regenerative Medicine

Published:2023-09-19 Issue:12 Volume:41 Page:1101-1112
ISSN:1066-5099
Container-title:Stem Cells
language:en
Short-container-title:

Author:

Wu Yinghua¹²,Ye Wenrui¹²,Gao Yong³,Yi Zhenjie¹²,Chen Zhuohui¹²,Qu Chunrun¹²,Huang Jing⁴,Liu Fangkun¹^ORCID,Liu Zhixiong¹²^ORCID

Affiliation:

1. Department of Neurosurgery, Xiangya Hospital, Central South University (CSU) , Changsha, Hunan , People’s Republic of China

2. Department of neurosurgery, Hypothalamic Pituitary Research Center, Xiangya Hospital, Central South University , Changsha, Hunan , People’s Republic of China

3. Orthopedics Department, The First People’s Hospital of Changde City , Changde, Hunan , People’s Republic of China

4. Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University , Changsha, Hunan , People’s Republic of China

Abstract

Abstract Regenerative medicine mainly relies on heterologous transplantation, often hindered by sample availability and ethical issues. Furthermore, patients are required to take immunosuppressive medications to prevent adverse side effects. Stem cell-derived 3D-organoid culture has provided new alternatives for transplantation and regenerative medicine. Scholars have combined organoids with tissue engineering technology to improve reproducibility, the accuracy of constitution and throughput, and genetic correction to achieve a more personalized therapy. Here, we review the available applications of organoids in regenerative medicine and the current challenges concerning this field.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

Link

https://academic.oup.com/stmcls/advance-article-pdf/doi/10.1093/stmcls/sxad072/51938937/sxad072.pdf

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