An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses

Author:

Temte Vidar1,Kjeldstadli Kari2,Bruun Lina Dorthea1,Birdal Morris1,Bachs Liliana1,Karinen Ritva1,Middelkoop Gerrit1,Øiestad Elisabeth13,Høiseth Gudrun14

Affiliation:

1. Department of Forensic Sciences,Oslo University Hospital Nydalen, Oslo, Norway

2. Department of Pharmacology, Oslo University Hospital, Oslo, Norway

3. School of Pharmacy, University of Oslo, Blindern, Oslo, Norway

4. Center for Psychopharmacology, Diakonhjemmet Hospital, Diakonveien 12, Oslo, Norway

Publisher

Oxford University Press (OUP)

Subject

Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology,Environmental Chemistry,Analytical Chemistry

Reference27 articles.

1. Urinary excretion of diazepam metabolites in healthy volunteers and drug users;Smith-Kielland;Scandinavian Journal of Clinical and Laboratory Investigation,2001

2. Alprazolam pharmacokinetics, metabolism, and plasma levels: clinical implications;Greenblatt;Journal of Clinical Psychiatry,1993

3. Detection of diazepam in urine, hair and preserved oral fluid samples with LC–MS-MS after single and repeated administration of Myolastan and Valium;Laloup;Analytical and Bioanalytical Chemistry,2007

4. Extending the detection window of diazepam by directly analyzing its glucuronide metabolites in human urine using liquid chromatography-tandem mass spectrometry;Wang;Journal of Chromatography. A,2012

5. Detection of diazepam and determination of time of ingestion;McBurney;Journal of the Canadian Society of Forensic Science,1981

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