Development of a collapsed cone convolution/superposition dose calculation algorithm with a mass density-specific water kernel for magnetic resonance-guided radiotherapy

Author:

Ito Kengo12,Ishikawa Yojiro1,Teramura Satoshi1,Kadoya Noriyuki2,Katsuta Yoshiyuki2,Tanaka Shohei2,Takeda Ken3,Jingu Keiichi2,Yamada Takayuki1

Affiliation:

1. Tohoku Medical and Pharmaceutical University Division of Radiology, , Sendai, Miyagi 983-8536 , Japan

2. Tohoku University Graduate School of Medicine Department of Radiation Oncology, , Sendai, Miyagi 980-8574 , Japan

3. Tohoku University Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, , Sendai, Miyagi 980-8575 , Japan

Abstract

Abstract This study aimed to develop and validate a collapsed cone convolution for magnetic resonance-guided radiotherapy (CCCMR). The 3D energy deposition kernels (EDKs) were generated in water in a 1.5-T transverse magnetic field. The CCCMR corrects the inhomogeneity in simulation geometry by referring to the EDKs according to the mass density between the interaction and energy deposition points in addition to density scaling. Dose distributions in a water phantom and in slab phantoms with inserted inhomogeneities were calculated using the Monte Carlo (MC) and CCCMR. The percentage depth dose (PDD) and off-axis ratio (OAR) were compared, and the gamma passing rate (3%/2 mm) was evaluated. The CCCMR simulated asymmetric dose distributions in the simulation phantoms, especially the water phantom, and all PDD and OAR profiles were in good agreement with the findings of the MC. The gamma passing rates were >99% for each field size and for the entire region. In the inhomogeneity phantoms, although the CCCMR underestimated dose in the low mass density regions, it could reconstruct dose changes at mass density boundaries. The gamma passing rate for the entire region was >95% for the field size of 2 × 2 cm2, but it was 68.9–86.7% for the field sizes of ≥5 × 5 cm2. Conclusively, in water, the CCCMR can obtain dose distributions comparable to those with the MC. Although the dose differences between them were mainly in inhomogeneity regions, the possibility of the effective use of the CCCMR in small field sizes was demonstrated.

Funder

JSPS

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Radiology, Nuclear Medicine and imaging,Radiation

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