1. North West Cancer Research Fund Institute, Bangor University, Bangor, Gwynedd LL57 2UW, UK, 2Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Petersgasse 14, 8010, Austria, 3NISCHR Cancer Genetics Biomedical Research Unit, Bangor University, Bangor, Gwynedd LL57 2UW, UK and 4Cranfield Health, Cranfield University, Cranfield, Bedfordshire MK43 0AL, UK