1. University of Rostock, Department of Computer Science, Albert-Einstein-Straße 22, D-18059 Rostock, Germany, 2 Department of Systems Biology and Bioinformatics, University of Rostock, Ulmenstrasse 69, 18057 Rostock, Germany and 3 Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch 7600, South Africa