1. Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06123 Perugia, Italy, 2Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, via Elce di Sotto 8, 06123, Perugia, Italy and 3European Institute of Oncology, Via Ripamonti, Milan 20141, Italy