Current practices in the delivery of pharmacogenomics: Impact of the recommendations of the Pharmacy Practice Model Summit

Author:

Valgus John1,Weitzel Kristin W2,Peterson Josh F3,Crona Daniel J4,Formea Christine M5

Affiliation:

1. Hematology/Oncology Pharmacy Services, University of North Carolina Healthcare, and UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC

2. UF Health Personalized Medicine Program, University of Florida, and Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL

3. Vanderbilt University Medical Center, Nashville, TN

4. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC

5. Mayo Clinic College of Medicine, Hospital Pharmacy Services, Mayo Clinic, Rochester, MN

Abstract

AbstractPurposeThis report examines and evaluates pharmacogenomics as an emerging science as it relates to the Practice Advancement Initiative and its predecessor the Pharmacy Practice Model Initiative’s consensus statements for optimal pharmacy practice models.SummaryPharmacogenomics is one of many emerging sciences to impact medication management and delivery of patient care. Increasingly, biomarkers are included in drug labeling and can assist pharmacists with personalizing medicine to optimize patient therapies and avoid adverse effects. The 2011 ASHP Pharmacy Practice Model Summit generated a list of 147 consensus statements for optimal pharmacy practice. Of these, 1 statement explicitly describes adjustment of drug regimens based on genetic factors as an essential activity of pharmacist-provided drug regimens, and 9 other statements provide additional support for incorporation of this emerging science into all aspects of patient care provided by pharmacists. We describe 4 institutions that have made significant inroads to implementing pharmacogenomics, to provide a framework and serve as resources for other institutions initiating their own pharmacogenomics implementation journeys.ConclusionThrough prioritized efforts of the pharmacy profession and health care institutions, pharmacogenomics will be disseminated and implemented, and the goal of the Pharmacy Practice Model Initiative’s consensus statements of improving health care using patients’ genetic characteristics will be realized.

Funder

National Institutes of Health

NCATS UF CTSA

IGNITE

Publisher

Oxford University Press (OUP)

Subject

Health Policy,Pharmacology

Reference18 articles.

1. Executive summary;Pharmacy Practice Model Summit;Am J Health-Syst Pharm.,2011

2. Genomics and drug response;Wang;N Engl J Med.,2011

3. The consensus of the Pharmacy Practice Model Summit;Am J Health-Syst Pharm.,2011

4. Electronic health record design and implementation for pharmacogenomics: a local perspective;Peterson;Genet Med.,2013

5. Preemptive clinical pharmacogenetics implementation: current programs in 5 US medical centers;Dunnenberger;Annu Rev Pharmacol Toxicol.,2015

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