Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma

Author:

Shiga Yukihiro12,Akiyama Masato1,Nishiguchi Koji M23,Sato Kota24,Shimozawa Nobuhiro5,Takahashi Atsushi16,Momozawa Yukihide7,Hirata Makoto8,Matsuda Koichi9,Yamaji Taiki10,Iwasaki Motoki10,Tsugane Shoichiro11,Oze Isao12,Mikami Haruo13,Naito Mariko14,Wakai Kenji14,Yoshikawa Munemitsu15,Miyake Masahiro15,Yamashiro Kenji1516,Kashiwagi Kenji17,Iwata Takeshi18,Mabuchi Fumihiko17,Takamoto Mitsuko19,Ozaki Mineo2021,Kawase Kazuhide22,Aihara Makoto19,Araie Makoto23,Yamamoto Tetsuya22,Kiuchi Yoshiaki24,Nakamura Makoto25,Ikeda Yasuhiro26,Sonoda Koh-Hei26,Ishibashi Tatsuro26,Nitta Koji27,Iwase Aiko28,Shirato Shiroaki29,Oka Yoshitaka30,Satoh Mamoru31,Sasaki Makoto31,Fuse Nobuo32,Suzuki Yoichi33,Cheng Ching-Yu343536,Khor Chiea Chuen37,Baskaran Mani3435,Perera Shamira34,Aung Tin343536,Vithana Eranga N34,Cooke Bailey Jessica N38,Kang Jae H39,Pasquale Louis R40,Haines Jonathan L38,Wiggs Janey L40,Burdon Kathryn P4142ORCID,Gharahkhani Puya43,Hewitt Alex W4445,Mackey David A4146,MacGregor Stuart43,Craig Jamie E42,Allingham R Rand47,Hauser Micheal48,Ashaye Adeyinka49,Budenz Donald L50,Akafo Stephan51,Williams Susan E I52,Kamatani Yoichiro153,Nakazawa Toru234,Kubo Michiaki7, ,

Affiliation:

1. Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

2. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan

3. Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan

4. Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Miyagi, Japan

5. Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan

6. Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan

7. Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

8. Institute of Medical Science, The University of Tokyo, Tokyo, Japan

9. Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

10. Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan

11. Center for Public Health Sciences, National Cancer Center, Tokyo, Japan

12. Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan

13. Cancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, Japan

14. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

15. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan

16. Department of Ophthalmology, Otsu Red-Cross Hospital, Otsu, Japan

17. Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan

18. Division of Molecular and Cellular Biology, National Institute of Sensory Organs, Tokyo Medical Center, National Hospital Organization, Tokyo, Japan

19. Department of Ophthalmology, University of Tokyo, Tokyo, Japan

20. Ozaki Eye Hospital, Hyuga, Miyazaki, Japan

21. Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan

22. Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan

23. Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan

24. Department of Ophthalmology and Visual Sciences, Hiroshima University, Hiroshima, Japan

25. Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

26. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

27. Fukuiken Saiseikai Hospital, Fukui, Japan

28. Tajimi Iwase Eye Clinic, Tajimi, Japan

29. Yotsuya Shirato Eye Clinic, Tokyo, Japan

30. Oka Eye Clinic, Fukuoka, Japan

31. Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan

32. Department of Integrative Genomics, Tohoku Medical Megabank Organization, Miyagi, Japan

33. Department of Education and Training, Tohoku Medical Megabank Organization, Miyagi, Japan

34. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore

35. Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore

36. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

37. Genome Institute of Singapore, Singapore

38. Department of Population and Quantitative Health Sciences, Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH, USA

39. Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA, USA

40. Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

41. Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia

42. Department of Ophthalmology, Flinders University, Adelaide, SA, Australia

43. QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

44. Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, Australia

45. Department of Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia

46. Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, WA, Australia

47. Department of Ophthalmology, Duke University, Durham, NC, USA

48. Duke University Medical Center, Durham, NC, USA

49. Department of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria

50. Department of Ophthalmology, University of North Carolina at Chapel Hill, USA

51. University of Ghana School of Medicine and Dentistry, Ghana

52. Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, South Africa

53. Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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