The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex-Reference-Cited by-同舟云学术

The TMEM127 human tumor suppressor is a component of the mTORC1 lysosomal nutrient-sensing complex

Published:2018-03-14 Issue:10 Volume:27 Page:1794-1808
ISSN:0964-6906
Container-title:Human Molecular Genetics
language:en
Short-container-title:

Author:

Deng Yilun¹²,Qin Yuejuan¹,Srikantan Subramanya¹,Luo Anqi¹,Cheng Zi-Ming¹,Flores Shahida K¹,Vogel Kris S²,Wang Exing²,Dahia Patricia L M¹²³^ORCID

Affiliation:

1. Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA

2. Department of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA

3. Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA

Funder

Cancer Prevention and Research Institute of Texas

CPRIT

Department of Defense

NIH

NIA

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Link

http://academic.oup.com/hmg/article-pdf/27/10/1794/25087129/ddy095.pdf

Reference49 articles.

1. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma;Qin;Nat. Genet,2010

2. Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas;Yao;J. Am. Med. Assoc,2010

3. The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function;Qin;Hum. Mol. Genet,2014

4. Clinical and molecular features of renal and phaeochromocytoma/paraganglioma tumour association syndrome (RAPTAS): case series and literature review;Casey;J. Clin. Endocrinol. Metab,2017

5. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways;Palmieri;Hum. Mol. Genet,2011

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1. Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics;ELIFE;2024

2. Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics;eLife;2024-04-30

3. Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics;2024-03-22

4. Computational analysis of protein–protein interactions of cancer drivers in renal cell carcinoma;FEBS Open Bio;2023-11-27

5. TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation;Cell Reports;2023-09