Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress

Author:

Dai Chongshan1,Ciccotosto Giuseppe D.2,Cappai Roberto2,Wang Yang1,Tang Shusheng1,Xiao Xilong1,Velkov Tony3

Affiliation:

1. College of Veterinary Medicine, China Agricultural University, 2 Yuanmingyuan West Road, Beijing 100193, People’s Republic of China

2. Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia

3. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

National Science and Technology

Australian National Health and Medical Research Council (NHMRC)

Australian NHMRC Industry Career Development Level 1 Research Fellow

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Reference75 articles.

1. Pharmacology of polymyxins: new insights into an ′old′ class of antibiotics;Velkov;Future Microbiol,2013

2. Colistin versus polymyxin B for the treatment of patients with multidrug-resistant Gram-negative infections: a systematic review and meta-analysis;Vardakas;Int J Antimicrob Agents,2016

3. Infections caused by Acinetobacter baumannii susceptible only to polymyxin in a gynecologic oncology unit;Vorgias;Int J Gynaecol Obstet,2009

4. Colistin and polymyxin B in critical care;Michalopoulos;Crit Care Clin,2008

5. Effectiveness and nephrotoxicity of intravenous colistin for treatment of patients with infections due to polymyxin-only-susceptible (POS) Gram-negative bacteria;Falagas;Eur J Clin Microbiol Infect Dis,2006

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