Identification of sur2 mutation affecting the lifespan of fission yeast-Reference-Cited by-同舟云学术

Identification of sur2 mutation affecting the lifespan of fission yeast

Published:2021-06 Issue:12 Volume:368 Page:
ISSN:1574-6968
Container-title:FEMS Microbiology Letters
language:en
Short-container-title:

Author:

Kurauchi Tatsuhiro¹,Matsui Kotaro¹,Shimasaki Takafumi¹,Ohtsuka Hokuto¹^ORCID,Tsubouchi Satoshi²,Ihara Kunio³,Tani Motohiro⁴,Aiba Hirofumi¹^ORCID

Affiliation:

1. Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan

2. Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan

3. Center for Gene Research, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan

4. Department of Chemistry, Faculty of Sciences, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan

Abstract

ABSTRACT Yeast is a suitable model system to analyze the mechanism of lifespan. In this study, to identify novel factors involved in chronological lifespan, we isolated a mutant with a long chronological lifespan and found a missense mutation in the sur2+ gene, which encodes a homolog of Saccharomyces cerevisiae sphingolipid C4-hydroxylase in fission yeast. Characterization of the mutant revealed that loss of sur2 function resulted in an extended chronological lifespan. The effect of caloric restriction, a well-known signal for extending lifespan, is thought to be dependent on the sur2+ gene.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Institute for Fermentation, Osaka

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Microbiology

Link

http://academic.oup.com/femsle/advance-article-pdf/doi/10.1093/femsle/fnab070/38596473/fnab070.pdf

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