Antimicrobial and biofilm-disrupting nanostructured TiO2 coating demonstrating photoactivity and dark activity

Author:

Wasa Alibe1ORCID,Land Johann G2,Gorthy Rukmini2,Krumdieck Susan2,Bishop Catherine2,Godsoe William3,Heinemann Jack A1ORCID

Affiliation:

1. School of Biological Sciences, University of Canterbury, New Zealand

2. Department of Mechanical Engineering, University of Canterbury, New Zealand

3. Bio-Protection Centre, Lincoln University, 85084 Ellesmere Junction Road, Lincoln 7647, New Zealand

Abstract

ABSTRACT Antimicrobial materials are tools used to reduce the transmission of infectious microorganisms. Photo-illuminated titania (TiO2) is a known antimicrobial material. Used as a coating on door handles and similar surfaces, it may reduce viability and colonization by pathogens and limit their spread. We tested the survival of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Saccharomyces cerevisiae on a nano-structured TiO2-based thin film, called ‘NsARC’, and on stainless steel under a variety of light wavelengths and intensities. There was significantly less survival (P <0.001) of all the organisms tested on NsARC compared to inert uncoated stainless steel under all conditions. NsARC was active in the dark and possible mechanisms for this are suggested. NsARC inhibited biofilm formation as confirmed by scanning electron microscopy. These results suggest that NsARC can be used as a self-cleaning and self-sterilizing antimicrobial surface coating for the prevention and reduction in the spread of potentially infectious microbes.

Funder

Ministry for Business Innovation and Employment

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Microbiology

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