Clinical Performance of Plasma Metagenomic Sequencing in Immunocompromised Pediatric Patients

Author:

Lehman Alice C12ORCID,Goren Lea R3,Evans Michael D4,Toles Olivia1,Drozdov Daniel567ORCID,Andrews Shannon L1,McAllister Shane C1,Thielen Beth K1ORCID

Affiliation:

1. Division of Pediatric Infectious Diseases, University of Minnesota , Minneapolis , USA

2. Division of Infectious Diseases and International Medicine, University of Minnesota , Minneapolis , USA

3. University of Minnesota Medical School , Minneapolis , USA

4. Clinical and Translational Science Institute, University of Minnesota , Minneapolis , USA

5. Division of Pediatric Blood and Marrow Transplantation, University of Minnesota , Minneapolis , USA

6. Division of Stem Cell Transplantation and Children’s Research Center, University Children’s Hospital Zurich, University of Zürich , Zürich , Switzerland , and

7. Division of Pediatric Hematology and Oncology, Department of Pediatrics, Kantonsspital Aarau , Aarau , Switzerland

Abstract

The performance of plasma metagenomic next-generation sequencing was evaluated in an immunocompromised pediatric population. The clinical impact was limited, with management changes in 13% of cases. Moreover, organisms thought to be non-pathogenic were commonly detected. Prospective studies in specific populations are required to clarify the utility of this emerging technology.

Publisher

Oxford University Press (OUP)

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