Fatal Fulminant Cerebral Edema in Six Children With SARS-CoV-2 Omicron BA.2 Infection in Taiwan-Reference-Cited by-同舟云学术

Fatal Fulminant Cerebral Edema in Six Children With SARS-CoV-2 Omicron BA.2 Infection in Taiwan

Published:2022-11-12 Issue:2 Volume:12 Page:99-103
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Lin Jainn-Jim¹^ORCID,Tu Yi-Fang²,Chen Shyi-Jou³,Kuo Yung-Ting⁴,Jeng Mei-Jy⁵,Hsin-Ju Ko Mary⁶,Chiu Cheng-Hsun⁷

Affiliation:

1. Division of Pediatric Critical Care Medicine and Pediatric Neurocritical Care Center, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine , Taoyuan , Taiwan

2. Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan , Taiwan

3. Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan

4. Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, and Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University , Taipei , Taiwan

5. Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang Ming Chiao Tung University, and Neonatal Medical Care Center and Section of Neonatology, Department of Pediatrics, Taipei Veterans General Hospital , Taipei , Taiwan

6. Division of Pediatric Neurology, Department of Pediatrics, Hsinchu Mackay Memorial Hospital , Hsinchu , Taiwan

7. Molecular Infectious Disease Research Center, Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, Chang Gung University College of Medicine , Taoyuan , Taiwan

Abstract

AbstractAcute fulminant cerebral edema in children following SARS-CoV-2 infection has been rarely reported. Such patients frequently demonstrate rapid progression and are usually fatal. In this retrospective study, we describe the detailed clinical, laboratory, and neuroimaging features of six fatal cases in Taiwan. All patients had shock initially, five showed rapid progression to multiorgan failure and disseminated intravascular coagulation, and three developed acute respiratory distress syndromes. The inflammatory biomarkers in the first 3 days, including interleukin 6, ferritin, lactate dehydrogenase, and D-dimer, showed significant elevation in all cases. The hyperinflammatory response may play a role in the pathophysiology.

Funder

National Science and Technology Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piac116/47011899/piac116.pdf

Reference10 articles.

1. Neurologic involvement in children and adolescents hospitalized in the United States for COVID-19 or multisystem inflammatory syndrome;LaRovere;JAMA Neurol,2021

2. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium;Venkatesan;Clin Infect Dis,2013

3. Encephalitis in US children;Messacar;Infect Dis Clin North Am,2018