Utility of Methicillin-Resistant <i>Staphylococcus aureus</i> Nasal PCR Testing in Pediatric Patients With Suspected Respiratory Infections-Reference-Cited by-同舟云学术

Utility of Methicillin-Resistant Staphylococcus aureus Nasal PCR Testing in Pediatric Patients With Suspected Respiratory Infections

Published:2024-03-11 Issue:4 Volume:13 Page:242-245
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Baker Brooke¹,Hung Frances²,Smith Michael J³⁴,Erkanli Alaattin²,Greenhill Katherine¹,Hayes Jillian¹⁴^ORCID,Parish Alice²,Zhou Grace²,Moorthy Ganga S³⁴^ORCID,Deri Connor R¹⁴^ORCID

Affiliation:

1. Department of Pharmacy, Duke University Medical Center , Durham, North Carolina , USA

2. Department of Biostatistics and Bioinformatics, Duke University School of Medicine , Durham, North Carolina , USA

3. Department of Pediatrics, Duke University Medical Center , Durham, North Carolina , USA

4. Duke Center for Antimicrobial Stewardship and Infection Prevention , Durham, North Carolina , USA

Abstract

Abstract Observational studies in adults suggest nasal methicillin-resistant Staphylococcus aureus (MRSA) swabs have a high negative predictive value (NPV) for ruling out MRSA pneumonia, however, pediatric data are limited. This retrospective study of 505 pediatric patients found a 99.8% NPV among children with suspected respiratory infections.

Funder

National Institute of Child Health and Human Development

Fogarty International Center

National Institutes of Health

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piae023/57056021/piae023.pdf

Reference11 articles.

1. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis;Cosgrove;Clin Infect Dis,2003

2. Methicillin-susceptible and methicillin-resistant Staphylococcus aureus bacteremia: nationwide estimates of 30-day readmission, in-hospital mortality, length of stay, and cost in the United States;Inagaki;Clin Infect Dis,2019

3. Predictive value of methicillin-resistant Staphylococcus aureus (MRSA) nasal swab PCR assay for MRSA pneumonia;Dangerfield;Antimicrob Agents Chemother,2014

4. Nasal methicillin-resistant Staphylococcus aureus (MRSA) PCR testing reduces the duration of MRSA-targeted therapy in patients with suspected MRSA pneumonia;Baby;Antimicrob Agents Chemother,2017

5. The clinical utility of methicillin-resistant Staphylococcus aureus (MRSA) nasal screening to rule out MRSA pneumonia: a diagnostic meta-analysis with antimicrobial stewardship implications;Parente;Clin Infect Dis,2018