Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature-Reference-Cited by-同舟云学术

Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature

Published:2022-07-18 Issue:9 Volume:11 Page:408-412
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Bami Sakshi¹,Hidinger Jennifer²,Madni Arshia¹³,Hargest Virginia²,Schultz-Cherry Stacey²^ORCID,Cortez Valerie⁴,Cross Shane J⁵,Ward Deborah A⁵,Hayden Randall T⁶,Rubnitz Jeffrey⁷,Pui Ching-Hon⁶⁷,Khan Raja B⁸,Hijano Diego R²^ORCID

Affiliation:

1. Hospitalist Medicine Program, St. Jude Children’s Research Hospital , Memphis, Tennessee , USA

2. Department of Infectious Diseases, St. Jude Children’s Research Hospital , Memphis, Tennessee , USA

3. Division of Quality of Life and Palliative Care, St. Jude Children’s Research Hospital , Memphis, Tennessee , USA

4. Department of Molecular and Cell & Developmental Biology, University of California , Santa Cruz, California , USA

5. Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital , Memphis, Tennessee , USA

6. Department of Pathology, St. Jude Children’s Research Hospital , Memphis, Tennessee , USA

7. Department of Oncology, St. Jude Children’s Research Hospital , Memphis, Tennessee , USA

8. Division of Neurology, St. Jude Children’s Research Hospital , Memphis, Tennessee , USA

Abstract

Abstract Novel human astroviruses (HAstVs) have recently been implicated as rare causes of fatal encephalitis in immunocompromised patients, for which there is no proven treatment. We report 2 cases from our institution in which HAstV-VA1 was detected in the cerebrospinal fluid by metagenomic next-generation sequencing after the initial evaluation revealed no etiology.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/article-pdf/11/9/408/46164973/piac045.pdf

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