Clinical and Epidemiological Features of a Family Cluster of Symptomatic and Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Author:

Wolf Gerhard K1,Glueck Thomas2,Huebner Johannes3,Muenchhoff Maximilian45,Hoffmann Dieter46,French Lars E7,Keppler Oliver T45,Protzer Ulrike46

Affiliation:

1. Children’s Hospital Traunstein, LMU Munich, Traunstein, Germany

2. Division of Infectious Diseases, Kliniken Südostbayern, Trostberg, Germany

3. Division of Pediatric Infectious Disease, Dr. von Hauner Children`s Hospital, LMU Munich, Munich, Germany

4. German Center for Infection Research, Munich Partner Site, Germany

5. Max von Pettenkofer Institute, LMU Munich, Munich, Munich, Germany

6. Institute of Virology, School of Medicine, Technical University of Munich/Helmholtz Zentrum München, Munich, Germany

7. Department of Dermatology and Allergology, LMU University Hospital, Munich, Germany

Abstract

Abstract In a family experiencing coronavirus disease 2019, the parents and 2 children aged 2 and 5 years became infected but the youngest child was not infected. Both children initially shed infectious virus, but cleared the virus after 5 to 6 days in the nasopharynx. However, viral RNA was continuously detected in the children’s stool for more than 4 weeks.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Reference17 articles.

1. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany;Rothe;N Engl J Med,2020

2. Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study;Bi;Lancet Infect Dis.

3. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia;Li;N Engl J Med,2020

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