Performance of a Molecular Test for Group A Streptococcus Pharyngitis

Author:

Tanz Robert R12,Heaberlin Lauren E12,Harvey Erin23,Katsogridakis Yiannis L23,Burns Rebecca Ruhana23,Rippe Jason4,Shulman Stanford T25

Affiliation:

1. Department of Pediatrics, Division of Advanced General Pediatrics & Primary Care, Ann & Robert H. Lurie Children’s Hospital of Chicago , Chicago, Illinois , USA

2. Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA

3. Department of Pediatrics, Division of Emergency Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago , Chicago, Illinois , USA

4. Special Infectious Diseases Laboratory, Department of Pathology, Ann & Robert H. Lurie Children’s Hospital of Chicago , Chicago, Illinois , USA

5. Department of Pediatrics, Division of Infectious Diseases, Ann & Robert H. Lurie Children’s Hospital of Chicago , Chicago, Illinois , USA

Abstract

Abstract We performed a prospective study to determine if the pretest probability of a positive loop-mediated isothermal amplification test is greater when there are more signs and symptoms of GAS pharyngitis. Patients were enrolled if a clinician obtained a GAS RADT. The McIsaac score was calculated. The prevalence of positive LAMP and RADT results increased as the McIsaac score increased. The calculated sensitivity of LAMP was superior to RADT.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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