Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016

Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016–2017 Season

Published:2018-12-27 Issue:1 Volume:9 Page:71-74
ISSN:2048-7193
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Rao Suchitra¹²³,Martin Jan⁴,Ahearn M Alex²,Osborne Christina⁵,Moss Angela²⁶,Dempsey Amanda⁵⁶,Dominguez Samuel R¹³⁷⁸,Weinberg Adriana¹⁹¹⁰,Messacar Kevin B¹²

Affiliation:

1. Division of Infectious Diseases, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

2. Division of Hospital Medicine, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

3. Division of Epidemiology, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

4. Division of Neurology, Department of Pediatrics, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

5. Department of Pediatrics, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

6. Adult and Child Center for Health Outcomes Research and Delivery Science, Aurora, Colorado

7. Division of Pathology, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

8. Division of Laboratory, Department of Pediatrics, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

9. Department of Medicine, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

10. Department of Pathology, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora

Abstract

Abstract Among 182 children with influenza infection in 2016–2017, 18% had neurologic manifestations of influenza (NMI), including seizures and encephalopathy; 85% of these children were infected with the H3N2 strain. Children with NMI had 3.5-times-higher odds of having a neurologic comorbidity than those without NMI and a 10-fold increased odds of hospitalization.

Funder

National Institutes of Health

National Center for Research Resources

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

http://academic.oup.com/jpids/article-pdf/9/1/71/33430531/piy130.pdf

Reference12 articles.

1. Neurologic complications of influenza;Ekstrand;Semin Pediatr Neurol,2012

2. The spectrum and burden of influenza-associated neurological disease in children: combined encephalitis and influenza sentinel site surveillance from Australia, 2013–2015;Britton;Clin Infect Dis,2017