The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children-Reference-Cited by-同舟云学术

The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children

Published:2022-12-20 Issue:3 Volume:12 Page:169-172
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Simpson Brittany N¹²,Mejía Sang Miguel E³,Collado Puello Yonairy³,Diaz Brockmans Elvira J⁴,Díaz Soto María F³,Rivera Defilló Stephanie M³,Taveras Cruz Karla M³,Santiago Pérez Javier O³,Husami Ammar¹,Day Melissa E⁵^ORCID,Pilipenko Valentina¹,Mena Rafael⁶,Mota Cesár⁷,Hostetter Margaret K²,Muglia Louis J¹²⁸,Schlaudecker Elizabeth²⁹,Gonzalez del Rey Javier²¹⁰,Martin Lisa J¹²,Prada Carlos E¹²¹¹¹²

Affiliation:

1. Division of Human Genetics, Cincinnati Children’s Hospital Medical Center , Cincinnati, Ohio , USA

2. Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati Children’s Hospital Medical Center , Cincinnati, Ohio , USA

3. Instituto Tecnológico de Santo Domingo, School of Medicine , Santo Domingo , Dominican Republic

4. School of Medicine, Universidad Iberamericana (UNIBE) , Santo Domingo , Dominican Republic

5. Department of Pediatrics, Cincinnati Children’s Hospital Medical Center , Cincinnati, Ohio , USA

6. Centro de Obstetricia y Ginecología , Santo Domingo , Dominican Republic

7. Pediatric Emergency Medicine Department, Hospital Infantil Dr. Robert Reid , Santo Domingo , Dominican Republic

8. Burroughs Welcome Fund , Research Triangle Park, North Carolina , USA

9. Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center , Cincinnati, Ohio , USA

10. Division of Pediatric Emergency Medicine, Cincinnati Children’s Hospital Medical Center , Cincinnati, Ohio , USA

11. Division of Genetics, Genomics & Metabolism, Ann & Robert H. Lurie Children’s Hospital of Chicago , Chicago, Illinois , USA

12. Department of Pediatrics, Feinberg School of Medicine of Northwestern University , Chicago, Illinois , USA

Abstract

Abstract We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.

Funder

Cincinnati Children's Hospital Medical Center

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/advance-article-pdf/doi/10.1093/jpids/piac136/48251298/piac136.pdf

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