Effect of Hepatitis C Virus Coinfection on the Progression of Vertically Acquired Human Immunodeficiency Virus Infection During Childhood and Adolescence

Author:

Fernández-McPhee Carolina12,Sainz Talía3,Mellado María José45,Noguera-Julian Antoni678,Otero Carmen9,Fortuny Claudia678,Soler-Palacín Pere10,Falcón María Dolores1112,Ramos Amador José Tomás1314,Gavilán César15,González-Tomé María Isabel16,Navarro María Luisa12

Affiliation:

1. Departments of Pediatric Infectious Diseases, University Hospital Gregorio Marañón and Gregorio Marañón Research Institute (IiSGM), Madrid

2. Spain Universidad Complutense de Madrid, Spain

3. Department of Pediatric Infectious Diseases, University Hospital La Paz and La Paz Research Institute (IdiPAZ), Madrid, Spain

4. Department of Pediatrics, Universidad Autonoma de Madrid, Madrid, Spain

5. Department of Pediatric Infectious Diseases, Universidad Autónoma de Madrid, Spain

6. Unit of infectious Diseases and Systemic Inflammatory Response and Hospital Sant Joan de Déu Research Institute, Barcelona, Spain

7. Department of Pediatrics, Universidad de Barcelona, Barcelona Spain

8. CIBER in Epidemiology and Public Health, CIBERESP, Madrid, Spain

9. Department of Pediatric Infectious Diseases, University Hospital La Fe, Valencia, Spain

10. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Spain

11. Pediatric Infectious Diseases, Immunology and Rheumatology Unit, University Hospital Virgen del Rocío, Sevilla, Spain

12. Pediatric Infectious Diseases, Immunology and Rheumatology Unit, Instituto de Biomedicina de Sevilla (IBiS), Spain

13. Department of Pediatrics, Hospital Clinico San Carlos and Hospital Clinico San Carlos Research Institute, Madrid, Spain

14. Department of Pediatrics, Universidad Complutense de Madrid, Madrid, Spain

15. Department of Pediatrics, University Hospital Sant Joan d’Alacant, Alicante, Spain

16. Pediatric Infectious Diseases and HIV Unit, University Hospital 12 de Octubre, Madrid, Spain

Abstract

Abstract Data for a total of 57 patients vertically coinfected with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) and 365 HIV-monoinfected patients were compared until their transition to adult care. No differences regarding the dynamics of CD4 and/or CD8 T-cell counts during childhood were found. The coexistence of HCV does not increase the risk of disease progression in vertically HIV-infected patients.

Funder

Spanish National Pediatric Network

Instituto de Salud Carlos III, Spanish Health Ministry

Spanish Society of Pediatric Infectious Diseases

Spanish Ministry of Health–

Instituto de Salud Carlos III

European Union

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology, and Child Health

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