Follow-up and Clinical Outcomes of Human Immunodeficiency Virus (HIV)–Exposed Infants in A Low-Prevalence Setting in A Multidisciplinary Model of Care in Australia: The Children’s HIV Exposure Study 1

Author:

Shepherd Kathryn1,Giles Michelle234,Blyth Karen1234,O’Keeffe Fiona1234,Bordun Louise5,Connell Tom G167,Bryant Penelope A167

Affiliation:

1. Infectious Diseases Unit, Department of General Medicine, The Royal Children’s Hospital Melbourne, Melbourne, Australia

2. Monash Infectious Diseases, Monash Medical Centre, Melbourne, Australia

3. Department of Infectious Diseases, Royal Women’s Hospital, Melbourne, Australia

4. Infectious Diseases Unit, Alfred Hospital, Melbourne, Australia

5. Pharmacy Department, The Royal Children’s Hospital Melbourne, Melbourne, Australia

6. Clinical Paediatrics, Murdoch Children’s Research Institute, Melbourne, Australia

7. Department of Paediatrics, University of Melbourne, Melbourne, Australia

Abstract

Abstract Background Prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) is effective, but outcome information beyond the postnatal period in low-prevalence settings is scarce. A multidisciplinary model of care (MOC) was developed to ensure PMTCT. Our aims in this study were to assess how well HIV-exposed infants are followed up through this MOC and to determine infant outcomes to age 18 months. Methods This was a multicenter, prospective study of infants exposed to HIV during pregnancy, born 1 September 2009–31 August 2016 in Victoria, Australia. Results There were 129 live births from 127 pregnancies. There were no episodes of HIV transmission. Sixteen (13%) infants were born prematurely, 15 (12%) had low birthweight, and 6 (5%) had a congenital anomaly. There were 122 (95%) infants with an HIV polymerase chain reaction (PCR) within 2 weeks of birth. The proportion in the MOC reduced from 95% at 2 weeks postnatally to 75% by 18 months. Eighty-eight percent cared for within the MOC had 2 viral PCR tests completed after stopping antiretroviral prophylaxis compared with 22% of those outside of the MOC. By 18 months, 84/126 (67%) children attended follow-up, with higher rates within the MOC than outside (76% vs 6%; odds ratio, 46; 95% confidence interval, 6 to 365; P < .001). Conclusions HIV-exposed, uninfected infants in this low-prevalence setting had good prospective follow-up through this MOC to 3 months. The decrease in follow-up by 18 months could be addressed in several ways, including expanding the MOC and providing better links to regional/rural services.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Reference24 articles.

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