Clinical Presentation and Severity of Adenovirus Detection Alone vs Adenovirus Co-detection With Other Respiratory Viruses in US Children With Acute Respiratory Illness from 2016 to 2018-Reference-Cited by-同舟云学术

Clinical Presentation and Severity of Adenovirus Detection Alone vs Adenovirus Co-detection With Other Respiratory Viruses in US Children With Acute Respiratory Illness from 2016 to 2018

Published:2022-07-18 Issue:10 Volume:11 Page:430-439
ISSN:2048-7207
Container-title:Journal of the Pediatric Infectious Diseases Society
language:en
Short-container-title:

Author:

Probst Varvara¹,Spieker Andrew J²,Stopczynski Tess²,Stewart Laura S¹,Haddadin Zaid¹^ORCID,Selvarangan Rangaraj³^ORCID,Harrison Christopher J³,Schuster Jennifer E⁴,Staat Mary A⁵,McNeal Monica⁵,Weinberg Geoffrey A⁶^ORCID,Szilagyi Peter G⁶⁷,Boom Julie A⁸,Sahni Leila C⁸,Piedra Pedro A⁸⁹,Englund Janet A¹⁰,Klein Eileen J¹⁰,Michaels Marian G¹¹,Williams John V¹¹,Campbell Angela P¹²,Patel Manish¹²,Gerber Susan I¹²,Halasa Natasha B¹

Affiliation:

1. Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Vanderbilt University , Nashville, Tennessee , USA

2. Department of Biostatistics, Vanderbilt University Medical Center , Nashville, Tennessee , USA

3. Department of Pathology and Laboratory Medicine, University of Missouri-Kansas City and Children’s Mercy Hospital , Kansas City, Missouri , USA

4. Department of Pediatrics, University of Missouri-Kansas City and Children’s Mercy Kansas City , Kansas City, Missouri , USA

5. Department of Pediatrics, College of Medicine, University of Cincinnati and Division of Infectious Diseases, Cincinnati Children’s Hospital , Cincinnati, Ohio , USA

6. Department of Pediatrics, School of Medicine and Dentistry, University of Rochester , Rochester, New York , USA

7. Department of Pediatrics, University of California at Los Angeles Mattel Children’s Hospital and University of California at Los Angeles , Los Angeles, California , USA

8. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, Texas Children’s Hospital , Houston, Texas , USA

9. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas. Texas Children’s Hospital , Houston, Texas , USA

10. Department of Pediatrics, University of Washington School of Medicine and Seattle Children’s Hospital , Seattle, Washington , USA

11. Department of Pediatrics, School of Medicine, University of Pittsburgh and University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh , Pittsburgh, Pennsylvania , USA

12. Division of Viral Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA

Abstract

Abstract Background Human adenovirus (HAdV) is commonly associated with acute respiratory illnesses (ARI) in children and is also frequently co-detected with other viral pathogens. We compared clinical presentation and outcomes in young children with HAdV detected alone vs co-detected with other respiratory viruses. Methods We used data from a multicenter, prospective, viral surveillance study of children seen in the emergency department and inpatient pediatric settings at seven US sites. Children less than 18 years old with fever and/or respiratory symptoms were enrolled between 12/1/16 and 10/31/18 and tested by molecular methods for HAdV, human rhinovirus/enterovirus (HRV/EV), respiratory syncytial virus (RSV), parainfluenza (PIV, types 1–4), influenza (flu, types A-C), and human metapneumovirus (HMPV). Our primary measure of illness severity was hospitalization; among hospitalized children, secondary severity outcomes included oxygen support and length of stay (LOS). Results Of the 18,603 children enrolled, HAdV was detected in 1,136 (6.1%), among whom 646 (56.9%) had co-detection with at least one other respiratory virus. HRV/EV (n = 293, 45.3%) and RSV (n = 123, 19.0%) were the most frequent co-detections. Children with HRV/EV (aOR = 1.61; 95% CI = [1.11–2.34]), RSV (aOR = 4.48; 95% CI = [2.81–7.14]), HMPV (aOR = 3.39; 95% CI = [1.69–6.77]), or ≥ 2 co-detections (aOR = 1.95; 95% CI = [1.14–3.36]) had higher odds of hospitalization compared to children with HAdV alone. Among hospitalized children, HAdV co-detection with RSV or HMPV was each associated with higher odds of oxygen support, while co-detection with PIV or influenza viruses was each associated with higher mean LOS. Conclusions HAdV co-detection with other respiratory viruses was associated with greater disease severity among children with ARI compared to HAdV detection alone.

Funder

US Centers for Disease Control and Prevention

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

Link

https://academic.oup.com/jpids/article-pdf/11/10/430/46621611/piac066.pdf

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