Clinical Influenza Testing Practices in Hospitalized Children at United States Medical Centers, 2015-2018

Author:

Tenforde Mark W1,Campbell Angela P1,Michaels Marian G2,Harrison Christopher J3,Klein Eileen J4,Englund Janet A4,Selvarangan Rangaraj3ORCID,Halasa Natasha B5,Stewart Laura S5,Weinberg Geoffrey A6ORCID,Williams John V2,Szilagyi Peter G7,Staat Mary A8,Boom Julie A910,Sahni Leila C910,Singer Monica N11,Azimi Parvin H11,Zimmerman Richard K12,McNeal Monica M13,Talbot H Keipp5,Monto Arnold S14,Martin Emily T14,Gaglani Manjusha15ORCID,Silveira Fernanda P12,Middleton Donald B12,Ferdinands Jill M1,Rolfes Melissa A1

Affiliation:

1. Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

3. University of Missouri—Kansas City School of Medicine, Children’s Mercy—Kansas City, Kansas City, Missouri, USA

4. Department of Pediatrics, Seattle Children’s Hospital, Seattle, Washington, USA

5. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA

6. Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

7. Department of Pediatrics, UCLA Mattel Children’s Hospital, Los Angeles, California, USA

8. Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

9. Texas Children’s Hospital, Houston, Texas, USA

10. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA

11. Department of Infectious Diseases, UCSF Benioff Children’s Hospital Oakland, Oakland, California, USA

12. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

13. Department of Pediatrics, University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

14. Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA

15. Baylor Scott and White Health, Texas A&M University College of Medicine, Temple, Texas, USA

Abstract

Abstract At nine US hospitals that enrolled children hospitalized with acute respiratory illness (ARI) during 2015-2016 through 2017-2018 influenza seasons, 50% of children with ARI received clinician-initiated testing for influenza and 35% of cases went undiagnosed due to lack of clinician-initiated testing. Marked heterogeneity in testing practice was observed across sites.

Funder

Centers for Disease Control and Prevention

National Institutes of Health

National Center for Advancing Translational Sciences Clinical Translational Science Award Program

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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